The endoplasmic-reticulum (ER) stress response constitutes a cellular process that is
triggered by a variety of conditions that disturb folding of proteins in the ER. Eukaryotic cells …

The endoplasmic reticulum (ER) is a highly dynamic organelle of fundamental importance
present in all eukaryotic cells. The majority of synthesized structural and secreted proteins …

The accumulation of unfolded proteins in the endoplasmic reticulum (ER) represents a
cellular stress induced by multiple stimuli and pathological conditions. These include …

In homeostasis, cellular processes are in a dynamic equilibrium. Perturbation of
homeostasis causes stress. In this review I summarize how perturbation of three major …

The endoplasmic reticulum (ER) is an organelle in which newly synthesized secretory and
transmembrane proteins are assembled and folded into their correct tertiary structures …

Research over the past few years has highlighted the ability of the unfolded protein
response (UPR) to minimize the deleterious effects of accumulated misfolded proteins under …

Unfolded proteins and other conditions affecting endoplasmic reticulum (ER) homeostasis
cause ER stress. The cell reacts to ER stress by activation of the unfolded protein response …

Protein-folding stress at the endoplasmic reticulum (ER) is a salient feature of specialized
secretory cells and is also involved in the pathogenesis of many human diseases. ER stress …

Endoplasmic reticulum (ER) stress is a common feature of several physiological and
pathological conditions affecting the function of the secretory pathway. To restore ER …

The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first
compartment of the secretory pathway. As such, the ER contributes to the production and …