Objective—Recent evidence suggests that dendritic cells may play an important role in
atherosclerosis. Based primarily on previous in vitro studies, we hypothesized that …

The granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hemopoietic growth
factor that regulates the production and functional activity of granulocytes and macrophages …

OBJECTIVE: To elucidate events that initiate the involvement and stimulation of fibroblasts in
systemic sclerosis (SSc). METHODS: We examined 15 patients with SSc diffuse form, 15 …

The factors that regulate the adherence of granulocytes to the endothelium under normal
conditions, and in states of inflammatory vascular injury, are largely unknown. We found that …

P-selectin glycoprotein-1 (PSGL-1) supports P-selectin–dependent rolling in vivo and in
vitro. However, controversy exists regarding the importance of PSGL-1–dependent and …

Smooth muscle cells (SMC) are the major cell type found in the walls of large blood vessels
and appear to participate in local immune and inflammatory reactions, as well as in certain …

Definitive hematopoietic stem cells arise in the aorta–gonad–mesonephros (AGM) region
from hemangioblasts, common precursors for hematopoietic and endothelial cells …

Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is now undergoing
clinical trials. We investigated the effects of rhG-CSF on the function of neutrophils in vivo in …

The host defense response critically depends on the production of leukocytes by the marrow
and the controlled delivery of these cells to relevant sites of inflammation/infection. The …

Thrombin-stimulated endothelium synthesizes numerous adhesion molecules to recruit
leukocytes; however, it is unknown which intracellular pathways are responsible for this …