Innate immunity is regulated by a broad set of evolutionary conserved receptors to finely
probe the local environment and maintain host integrity. Besides pathogen recognition …

The innate immune system is critically important for the primary sensing of invading
pathogens. Over the past decade, the cellular sensors important for recognizing microbial …

The first line of host defense against infectious agents involves activation of innate immune
signaling pathways that recognize specific pathogen-associated molecular patterns …

Inflammatory autoimmune diseases such as systemic lupus erythematosus (SLE) and
polyarthritis are characterized by chronic cytokine overproduction, suggesting that the …

One of the oldest mechanisms of immune defense against pathogens is through detection of
foreign DNA. Since human DNA is compartmentalized into the nucleus, its presence in the …

DNA is present in the nucleus and mitochondria of eukaryotic cells. There are, however,
certain instances in which DNA emerges in the cytosol. The two major sources of cytosolic …

Highlights•Self-DNA activates STING regulated autoinflammatory responses.•Nucleases
such as DNaseII and III prevent inflammation by degrading STING activators.•Gain of …

STING is a newly identified intracellular sensor of foreign and endogenous DNA. STING has
been recognized as an activator of immune responses by TBK1/IRF3 and NF‐κB pathways …

STING is a newly identified adaptor protein for sensing cytosolic nucleic acid. It is well
established that STING plays a crucial role in innate immune response via inducing …

How the cell recognizes cytosolic DNA including DNA-based microbes to trigger host-
defense-related gene activation remains to be fully resolved. Here, we demonstrate that …