Introduction Gut microbiota have been linked to modulating susceptibility to Type 1 diabetes;
however, there are many ways in which the microbiota interact with host cells, including …

In addition to high-fat diet (HFD) and inactivity, inflammation and microbiota composition
contribute to obesity. Inhibitory immune receptors, such as NLRP12, dampen inflammation …

Inflammatory bowel disease (IBD) is on the rise in the western world. 1 The dynamic
interplay between genetic susceptibility, the gut microbiome and host inflammatory reactions …

Intestinal epithelial cells play an important role in the maintenance of host microbiota as well
as intestinal homeostasis by expression of pattern recognition receptors (PRRs). NLRP6 …

The inflammasome is a platform for inflammatory signaling, and the NLRP3 inflammasome
recognizes stimuli in vitro and in vivo, and releases inflammatory cytokines that trigger …

Background Attenuated innate immune responses to the intestinal microbiota have been
linked to the pathogenesis of Crohn's disease (CD). Recent genetic studies have revealed …

NLRP12 has dual roles in shaping inflammation. We hypothesized that NLRP12 would
modulate myeloid cells and T cell function to control systemic autoimmunity. Contrary to our …

The gut microbiota regulate susceptibility to multiple human diseases. The Nlrp6-ASC
inflammasome is widely regarded as a hallmark host innate immune axis that shapes the gut …

Identification of the individual factors contributing to the formation of ''healthy''or disease-
modulating ''dysbiotic''microbiome communities is an important aspect of microbiome …

Inflammatory bowel diseases involve the dynamic interplay of host genetics, microbiome
and inflammatory response. Here, we report that NLRP12, a negative regulator of innate …