Neutrophil Hitchhiking Biomimetic Nanozymes Prime Neuroprotective Effects of Ischemic Stroke in a Tailored “Burning the Bridges” Manner

J Song, G Yang, Y Song, Z Jiang… - Advanced Functional …, 2024 - Wiley Online Library
Reperfusion injury of ischemic stroke, characterized by the uncontrolled production of
reactive oxygen species (ROS) and inflammatory reactions, continues to present a major …

Neutrophil-like cell-membrane-coated nanozyme therapy for ischemic brain damage and long-term neurological functional recovery

L Feng, C Dou, Y Xia, B Li, M Zhao, P Yu, Y Zheng… - ACS …, 2021 - ACS Publications
Oxidative stress and a series of excessive inflammatory responses are major obstacles for
neurological functional recovery after ischemic stroke. Effective noninvasive anti …

Hollow prussian blue nanozymes drive neuroprotection against ischemic stroke via attenuating oxidative stress, counteracting inflammation, and suppressing cell …

K Zhang, M Tu, W Gao, X Cai, F Song, Z Chen… - Nano …, 2019 - ACS Publications
Ischemic stroke is a devastating disease and one of the leading causes of mortality
worldwide. Overproduction of reactive oxygen and nitrogen species (RONS) following …

Nano-integrated cascade antioxidases opsonized by albumin bypass the blood–brain barrier for treatment of ischemia-reperfusion injury

W Wang, Z Zhang, Y Liu, L Kong, W Li, W Hu… - Biomaterials …, 2022 - pubs.rsc.org
Potent antioxidative drugs are urgently needed to treat ischemia-reperfusion (I/R) induced
reactive oxygen species (ROS)-mediated cerebrovascular and neural injury during ischemia …

A thrombin‐activated peptide‐templated nanozyme for remedying ischemic stroke via thrombolytic and neuroprotective actions

Z Wang, Y Zhao, Y Hou, G Tang, R Zhang… - Advanced …, 2024 - Wiley Online Library
Ischemic stroke (IS) is one of the most common causes of disability and death. Thrombolysis
and neuroprotection are two current major therapeutic strategies to overcome ischemic and …

Prussian blue nanozyme treatment of ischemic brain injury via reducing oxidative stress inhibits inflammation, suppresses apoptosis, and promotes neurological …

J Liu, J Sun, Y Song, M Wang, P Zhao… - ACS Chemical …, 2023 - ACS Publications
Ischemic stroke is one of the leading causes of death and severe disability. The
overproduction of reactive oxygen species (ROS) after ischemic injury causes a series of …

[HTML][HTML] Advances in antioxidative nanozymes for treating ischemic stroke

J Shan, X Liu, X Li, Y Yu, B Kong, L Ren - Engineered Regeneration, 2023 - Elsevier
Ischemic stroke is one of the most common public diseases that increase mortality. In the
ischemic brain, blood flow restoration can cause the generation of excess reactive oxygen …

An ischemia-homing bioengineered nano-scavenger for specifically alleviating multiple pathogeneses in ischemic stroke

R Duan, K Sun, F Fang, N Wang, R He, Y Gao… - Journal of …, 2022 - Springer
Background Ischemic stroke is one of the most serious global public health problems.
However, the performance of current therapeutic regimens is limited due to their poor target …

Relieving thrombo-inflammation with acid-triggered polymersomes toward ischemic stroke therapy

R Li, Z Wang, J Li, H Chen, X Guo, S Zhou - Nano Today, 2024 - Elsevier
In acute ischemic stroke, neutrophils contribute to ischemia-reperfusion injury through
producing neutrophil extracellular traps (NETs), which promote the interaction of platelets …

A Homing Peptide Modified Neutrophil Membrane Biomimetic Nanoparticles in Response to ROS/inflammatory Microenvironment for Precise Targeting Treatment of …

Z Dong, L Tang, Y Zhang, X Ma, Y Yin… - Advanced Functional …, 2024 - Wiley Online Library
Oxidative stress induced by ischemia‐reperfusion causes severe secondary injury in stroke
patients. The blood‐brain barrier (BBB) and the challenges in targeting the stroke core …