Macrophages are traditional innate immune cells that play critical roles in the clearance of
pathogens and the maintenance of tissue homeostasis. Accumulating evidence proves that …

The immune system plays an important role in the development of, and progression of
cancer. Macrophages exhibit a variety of responses according to varying stimuli, and …

The M1/M2 macrophage paradigm plays a key role in tumor progression. M1 macrophages
are historically regarded as anti-tumor, while M2-polarized macrophages, commonly …

Cancer research in recent decades has highlighted the potential influence of the tumor
microenvironment on the progression and metastasis of most known cancer types. Within …

Macrophages are a fundamental part of the innate defense mechanisms, which can promote
specific immunity by inducing T cell recruitment and activation. Despite this, their presence …

Tumor associated macrophages (TAMs), located in the tumor microenvironment (TME), play
a significant role in cancer cell survival and progression. TAMs have been involved in …

Tumor microenvironment consists of malignant and non-malignant cells. The interaction of
these dynamic and different cells is responsible for tumor progression at different levels. The …

Macrophages play an important role in tissue homeostasis, tissue remodeling, immune
response, and progression of cancer. Consequently, macrophages exhibit significant …

The macrophage is known to be a multifunctional antigen presenting cells and playing a
central role in inflammation. Macrophages infiltrate into malignant tumor tissues in high …

The occurrence and development of tumors depend on the tumor microenvironment (TME),
which consists of various types of cellular and acellular components. Tumor-associated …