Objective: The objective of this study was to build on the seminal paper by Tunis et al
(Practical clinical trials. Increasing the value of clinical research for decision making in …

Decision makers in health care are increasingly interested in using high-quality scientific
evidence to support clinical and health policy choices; however, the quality of available …

Clinical research should ultimately improve patient care. For this to be possible, trials must
evaluate outcomes that genuinely reflect real-world settings and concerns. However, many …

OBJECTIVE: This article is to establish recommendations for conducting quantitative
synthesis, or meta-analysis, using study-level data in comparative effectiveness reviews …

Background In healthcare research, results diffuse only slowly into clinical practice, and
there is a need to bridge the gap between research and practice. This study elucidates how …

Background: The interpretation of the results of randomized controlled trials (RCTs) has
traditionally emphasized statistical significance rather than clinical importance. Our aim was …

OBJECTIVE: To describe a systematic approach for identifying, reporting, and synthesizing
information to allow consistent and transparent consideration of the applicability of the …

Randomized controlled trials (RCTs) are conducted under idealized and rigorously
controlled conditions that may compromise their external validity. A literature review was …

The recent focus of federal funding on comparative effectiveness research underscores the
importance of clinical trials in the practice of evidence-based medicine and health care …

There are several methods in which one can assess the relationship between an
intervention and an outcome. Randomized controlled trials (RCTs) are considered as the …