[HTML][HTML] Synthesis, pharmacophore modeling, and cytotoxic activity of 2-thioxothiazolidin-4-one derivatives
Abstract A series of 2-thioxothiazolidin-4-one derivatives were efficiently synthesized and
evaluated for their cytotoxic activity against four tumor cell lines. The synthesized …
evaluated for their cytotoxic activity against four tumor cell lines. The synthesized …
Benzoxazole derivatives as new generation of anti-breast cancer agents
AMME Omar, OM AboulWafa, MS El-Shoukrofy… - Bioorganic …, 2020 - Elsevier
New 2-substituted benzoxazole derivatives were synthesized and screened for their in vitro
anti-proliferative activities against MCF-7 and MDA-MB-231 cell lines. Compounds 4b, 4d …
anti-proliferative activities against MCF-7 and MDA-MB-231 cell lines. Compounds 4b, 4d …
Novel fluorinated pyrazole-based heterocycles scaffold: cytotoxicity, in silico studies and molecular modelling targeting double mutant EGFR L858R/T790M as …
Hepatocellular carcinoma (HCC), also known as hepatoma, is the most prevalent type of
primary liver cancer. It begins in the hepatocytes, the liver's major cell type. Cancer that …
primary liver cancer. It begins in the hepatocytes, the liver's major cell type. Cancer that …
Novel coumarin–pyrazoline hybrids: synthesis, cytotoxicity evaluation and molecular dynamics study
A novel series of coumarin–pyrazoline hybrids 3a–f, 4a–c and 5a–c have been synthesized
and tested for their antiproliferative activity against the breast cancer cell line MCF-7. The …
and tested for their antiproliferative activity against the breast cancer cell line MCF-7. The …
Design, Synthesis and Cytotoxicity Screening of New Thiazole Derivatives as Potential Anticancer Agents through VEGFR-2 Inhibition
Z-configurated isomers are kinetically preferred molecules. Compounds with Z-configuration
are contained in many natural products, biologically active compounds and as synthons for …
are contained in many natural products, biologically active compounds and as synthons for …
New Indazol-Pyrimidine-Based Derivatives as Selective Anticancer Agents: Design, Synthesis, and In Silico Studies
HM Al-Tuwaijri, ES Al-Abdullah, AA El-Rashedy… - Molecules, 2023 - mdpi.com
In this research study, the authors successfully synthesized potent new anticancer agents
derived from indazol-pyrimidine. All the prepared compounds were tested for in vitro cell line …
derived from indazol-pyrimidine. All the prepared compounds were tested for in vitro cell line …
Dual kinase inhibition of EGFR/HER2: design, synthesis and molecular docking of thiazolylpyrazolyl‐based aminoquinoline derivatives as anticancer agents
RZ Batran, WA El‐Kashak, SM El‐Daly… - …, 2021 - Wiley Online Library
Two new series of aminoquinoline based derivatives (thiazolyl pyrazolines and pyrazolyl
thiazolidinones) were designed and synthesized. The in vitro antiporliferative activity of the …
thiazolidinones) were designed and synthesized. The in vitro antiporliferative activity of the …
Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives containing benzodioxole as potential anticancer agents
HH Wang, KM Qiu, HE Cui, YS Yang, M Xing… - Bioorganic & medicinal …, 2013 - Elsevier
A series of novel thiazolyl-pyrazoline derivatives containing benzodioxole (C1–C20) have
been designed and synthesized. Among of the synthesized compounds, 2-(5-(benzo [d][1, 3] …
been designed and synthesized. Among of the synthesized compounds, 2-(5-(benzo [d][1, 3] …
Design, synthesis and biological evaluation of new series of hexahydroquinoline and fused quinoline derivatives as potent inhibitors of wild-type EGFR and mutant …
MA Shaheen, AA El-Emam, NS El-Gohary - Bioorganic Chemistry, 2020 - Elsevier
New series of hexahydroquinoline and fused quinoline derivatives were designed and
synthesized. The thirty seven new compounds were screened for in vitro antitumor activity …
synthesized. The thirty seven new compounds were screened for in vitro antitumor activity …
Synthesis, Biological Evaluation and Molecular Docking of Novel Thiophene‐Based Indole Derivatives as Potential Antibacterial, GST Inhibitor and Apoptotic …
Heteroaromatic indoles play a leading role in the development of pharmaceutical, medical,
chemical and agricultural fields due to their structural properties. In this study, it was first time …
chemical and agricultural fields due to their structural properties. In this study, it was first time …