AMPK in neurodegenerative diseases

M Domise, V Vingtdeux - AMP-activated Protein Kinase, 2016 - Springer
Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral
sclerosis are neurodegenerative disorders that are characterized by a progressive …

AMPK in neurodegenerative diseases: implications and therapeutic perspectives

C Marinangeli, S Didier, V Vingtdeux - Current drug targets, 2016 - ingentaconnect.com
Maintaining proper energy levels in brain neurons is crucial for many cerebral functions
such as synaptic transmission, vesicle recycling and axonal transport. AMP-activated protein …

AMPK-mediated regulation of neuronal metabolism and function in brain diseases

YJ Liu, Y Chern - Journal of neurogenetics, 2015 - Taylor & Francis
The AMP-activated protein kinase (AMPK) is a serine/threonine kinase that functions as a
key energy sensor in a wide variety of tissues. This kinase has been a major drug target for …

AMPK in the brain: its roles in glucose and neural metabolism

R Muraleedharan, B Dasgupta - The FEBS Journal, 2022 - Wiley Online Library
The adenosine monophosphate‐activated protein kinase (AMPK) is an integrative metabolic
sensor that maintains energy balance at the cellular level and plays an important role in …

[HTML][HTML] Isoform-specific dysregulation of AMP-activated protein kinase signaling in a non-human primate model of Alzheimer's disease

X Wang, X Zhou, B Uberseder, J Lee, CS Latimer… - Neurobiology of …, 2021 - Elsevier
AMP-activated protein kinase (AMPK) is a molecular sensor that is critical for the
maintenance of cellular energy homeostasis, disruption of which has been indicated in …

AMPK activation: Role in the signaling pathways of neuroinflammation and neurodegeneration

CA Peixoto, WH de Oliveira, SM da Racho Araújo… - Experimental …, 2017 - Elsevier
Adenosine monophosphate-activated protein kinase (AMPK) is an evolutionarily conserved
sensor of cellular energy status and has been reported to be involved in chronic …

AMP‐activated protein kinase: a potential player in Alzheimer's disease

A Salminen, K Kaarniranta, A Haapasalo… - Journal of …, 2011 - Wiley Online Library
J. Neurochem.(2011) 118, 460–474. Abstract AMP‐activated protein kinase (AMPK)
stimulates energy production via glucose and lipid metabolism, whereas it inhibits energy …

Therapeutic potential of AMP-activated protein kinase in Alzheimer's disease

X Wang, HR Zimmermann, T Ma - Journal of Alzheimer's …, 2019 - content.iospress.com
Currently there is no cure or effective disease-modifying therapy for Alzheimer's disease
(AD), the most common form of dementia that is becoming a global threat to public health. It …

Roles of AMP-activated protein kinase in Alzheimer's disease

Z Cai, LJ Yan, K Li, SH Quazi, B Zhao - Neuromolecular medicine, 2012 - Springer
AMP-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis
and a central player in glucose and lipid metabolism, is potentially implicated in the …

AMP-activated protein kinase (AMPK) molecular crossroad for metabolic control and survival of neurons

MR Spasić, P Callaerts, KK Norga - The Neuroscientist, 2009 - journals.sagepub.com
AMP-activated protein kinase (AMPK) constitutes a molecular hub for cellular metabolic
control, common to all eukaryotic cells. Numerous reports have established how AMPK …