Insulin-secreting β-cells are heterogeneous in their regulation of hormone release. While
long known, recent technological advances and new markers have allowed the identification …

Although β-cell heterogeneity was discovered more than 50 years ago, the underlying
principles have been explored only during the past decade. Islet-cell heterogeneity arises …

Although it is well established that type 2 diabetes (T2D) is generally due to the progressive
loss of β-cell insulin secretion against a background of insulin resistance, the actual …

Endocrine cells within the pancreatic islets of Langerhans are heterogeneous in terms of
transcriptional profile, protein expression and the regulation of hormone release. Even …

It is becoming increasingly apparent that not all insulin-secreting beta cells are equal. Subtle
differences exist at the transcriptomic and protein expression levels, with repercussions for …

Following differentiation during fetal development, β cells further adapt to their postnatal role
through functional maturation. While adult islets are thought to contain functionally mature β …

Pancreatic β-cells play a pivotal role in maintaining normoglycemia. Recent studies have
revealed that the β-cell is not a homogeneous cell population but, rather, is heterogeneous …

The two main types of diabetes mellitus have distinct etiologies, yet a similar outcome: loss
of islet β-cell function that is solely responsible for the secretion of the insulin hormone to …

Metabolic homeostasis in mammals is tightly regulated by the complementary actions of
insulin and glucagon. The secretion of these hormones from pancreatic β-cells and α-cells …

Pancreatic β-cells perform glucose-stimulated insulin secretion, a process at the center of
type 2 diabetes etiology. Efforts to understand how β-cells behave in healthy and stressful …