Objective Dedifferentiation of pancreatic β-cells may reduce islet function in type 2 diabetes
(T2D). However, the prevalence, plasticity and functional consequences of this cellular state …

Insulin production by the pancreatic islet is tightly coupled to the concentration of blood
glucose. The mechanism by which glucose controls proinsulin biosynthesis in β cells is …

Within the pancreatic islet, the β-cell represents the ultimate biosensor. Its central function is
to accurately sense glucose levels in the blood and consequently release appropriate …

One hundred years have passed since the discovery of insulin—an achievement that
transformed diabetes from a fatal illness into a manageable chronic condition. The decades …

Emerging reports on the organization of the different hormone-secreting cell types (alpha,
glucagon; beta, insulin; and delta, somatostatin) in human islets have emphasized the …

Postnatal maintenance or regeneration of pancreatic beta cells is considered to occur
exclusively via the replication of existing beta cells, but clinically meaningful restoration of …

The control of hormone secretion is central to body homeostasis, and its dysfunction is
important in many diseases. The key cellular steps that lead to hormone secretion have …

Alpha and beta cells act in concert to maintain blood glucose. Alpha cells release glucagon
in response to low glucose to stimulate glycogenolysis in the liver. In contrast, beta cells …

The functional role of autocrine insulin signaling remains unclear despite considerable
investigation. In the present study, we tested the effects of high and low doses of exogenous …

Metabolic and secretory heterogeneity are fundamental properties of pancreatic islet β cells.
Emerging data suggest that stable differences in the transcriptome and proteome of …