The extracellular matrix polysaccharide hyaluronan (HA) exerts size-dependent effects on
leukocyte behavior. Low-molecular weight HA is abundant at sites of active tissue …

Accumulation and turnover of extracellular matrix components are the hallmarks of tissue
injury. Fragmented hyaluronan stimulates the expression of inflammatory genes by a variety …

Hyaluronan is a simple repeating disaccharide polymer, synthesized at the cell surface by
integral membrane synthases. The repeating sequence is perfectly homogeneous, and is …

Production of the glycosaminoglycan hyaluronan is increased at sites of inflammation, often
correlating with the accumulation of leukocytes. Mounting evidence suggests that this …

Hyaluronan is made and extruded from cells to form a pericellular or extracellular matrix
(ECM) and is present in virtually all tissues in the body. The size and form of hyaluronan …

CD44 is a cell surface receptor for the extracellular matrix glycosaminoglycan hyaluronan
and is involved in processes ranging from leukocyte recruitment to wound healing. In the …

Hyaluronan is a glycosaminoglycan present in the extracellular matrix. When hyaluronan is
degraded during infection and injury, low mw forms are generated whose interactions …

In the immune system, leukocyte activation induces CD44 to bind hyaluronan, a component
of the extracellular matrix. Here we used gain and loss of hyaluronan-binding mutants of …

The authors describe the immunoregulatory contributions of intact versus fragmented
hyaluronan, a prominent component of the extracellular matrix. The composition of the ECM …

Fragments of hyaluronan released after injury bind and activate TLR4 in a complex with
CD44. Here we investigated if the recognition of hyaluronan by CD44 and TLR4 alters …