In the past decade, over 1000 continuous human cell lines have been established from lung
cancer biopsy specimens. Numerous growth factors and receptors have been identified in …

We investigated the production, binding to cell membranes, and influence on cell
proliferation of peptides and growth factors in 4 classic, 5 transitional and 5 variant SCLC …

Purpose. Small cell lung cancer (SCLC) is a rapidly growing neoplasm accounting for
approximately 20% of patients with lung cancer. Progastrin-releasing peptide (proGRP) is …

A semiautomated colorimetric assay (MTT assay), based on the ability of live cells to reduce
a tetrazolium-based compound, 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium …

Gastrin‐releasing peptide (GRP) has previously been shown to be an autocrine growth
factor for small cell lung cancer, and our objective in the study presented here was to …

Gastrin-releasing peptide is an important growth-modulating factor in developing lung
epithelium. It is known to be produced by small cell carcinomas of the lung, and an autocrine …

Small cell lung cancer (SCLC) produces several neuroendocrine peptides, including gastrin-
releasing peptide (GRP), the mammalian equivalent of bombesin. There is some evidence …

Rapid proliferation in small cell lung cancer (SCLC) may be mediated by synthesis of
autocrine growth factors. Bombesin (or its mammalian homologue gastrin releasing peptide …

The binding of a radiolabeled bombesin analogue to human small cell lung cancer (SCLC)
cell lines was investigated.(125 I-Tyr 4) bombesin bound with high affinity (Kd= 0.5 nM) to a …

Gastrin-releasing peptide (GRP; mammalian bombesin) is present in the neuroendocrine
cells of human fetal lung and in small cell lung carcinomas (SCLCs), where it may act as a …