Genome-wide association study of brain connectivity changes for Alzheimer's disease
SSM Elsheikh, ER Chimusa, NJ Mulder, A Crimi - Scientific reports, 2020 - nature.com
Variations in the human genome have been found to be an essential factor that affects
susceptibility to Alzheimer's disease. Genome-wide association studies (GWAS) have …
susceptibility to Alzheimer's disease. Genome-wide association studies (GWAS) have …
Relating global and local connectome changes to dementia and targeted gene expression in Alzheimer's disease
SSM Elsheikh, ER Chimusa… - Frontiers in human …, 2021 - frontiersin.org
Networks are present in many aspects of our lives, and networks in neuroscience have
recently gained much attention leading to novel representations of brain connectivity. The …
recently gained much attention leading to novel representations of brain connectivity. The …
Identifying multimodal intermediate phenotypes between genetic risk factors and disease status in Alzheimer's disease
Neuroimaging genetics has attracted growing attention and interest, which is thought to be a
powerful strategy to examine the influence of genetic variants (ie, single nucleotide …
powerful strategy to examine the influence of genetic variants (ie, single nucleotide …
Integrating brain imaging endophenotypes with GWAS for Alzheimer's disease
KA Knutson, W Pan - Quantitative Biology, 2021 - Wiley Online Library
Background Genome wide association studies (GWAS) have identified many genetic
variants associated with increased risk of Alzheimer's disease (AD). These susceptibility loci …
variants associated with increased risk of Alzheimer's disease (AD). These susceptibility loci …
[HTML][HTML] Brain-wide genome-wide colocalization study for integrating genetics, transcriptomics and brain morphometry in Alzheimer's disease
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases.
However, the AD mechanism has not yet been fully elucidated to date, hindering the …
However, the AD mechanism has not yet been fully elucidated to date, hindering the …
Structural neuroimaging genetics interactions in Alzheimer's disease
SW Moon, ID Dinov, J Kim, A Zamanyan… - Journal of …, 2015 - content.iospress.com
This article investigates late-onset cognitive impairment using neuroimaging and genetics
biomarkers for Alzheimer's Disease Neuroimaging Initiative (ADNI) participants. Eight …
biomarkers for Alzheimer's Disease Neuroimaging Initiative (ADNI) participants. Eight …
[HTML][HTML] Multimodal brain imaging reveals structural differences in Alzheimer's disease polygenic risk carriers: a study in healthy young adults
Background Recent genome-wide association studies have identified genetic loci that jointly
make a considerable contribution to risk of developing Alzheimer's disease (AD). Because …
make a considerable contribution to risk of developing Alzheimer's disease (AD). Because …
Network-based analysis of genetic variants associated with hippocampal volume in Alzheimer's disease: a study of ADNI cohorts
Background Alzheimer's disease (AD) is a neurodegenerative disease that causes
dementia. While molecular basis of AD is not fully understood, genetic factors are expected …
dementia. While molecular basis of AD is not fully understood, genetic factors are expected …
Genetic study of multimodal imaging Alzheimer's disease progression score implicates novel loci
Identifying genetic risk factors underpinning different aspects of Alzheimer's disease has the
potential to provide important insights into pathogenesis. Moving away from simple case …
potential to provide important insights into pathogenesis. Moving away from simple case …
[HTML][HTML] Multimodal analysis of disease onset in Alzheimer's disease using Connectome, Molecular, and genetics data
Alzheimer's disease (AD) and its related age at onset (AAO) are highly heterogeneous, due
to the inherent complexity of the disease. They are affected by multiple factors, such as …
to the inherent complexity of the disease. They are affected by multiple factors, such as …