Genome-wide association study of brain connectivity changes for Alzheimer's disease

SSM Elsheikh, ER Chimusa, NJ Mulder, A Crimi - Scientific reports, 2020 - nature.com
Variations in the human genome have been found to be an essential factor that affects
susceptibility to Alzheimer's disease. Genome-wide association studies (GWAS) have …

Relating global and local connectome changes to dementia and targeted gene expression in Alzheimer's disease

SSM Elsheikh, ER Chimusa… - Frontiers in human …, 2021 - frontiersin.org
Networks are present in many aspects of our lives, and networks in neuroscience have
recently gained much attention leading to novel representations of brain connectivity. The …

Identifying multimodal intermediate phenotypes between genetic risk factors and disease status in Alzheimer's disease

X Hao, X Yao, J Yan, SL Risacher, AJ Saykin, D Zhang… - Neuroinformatics, 2016 - Springer
Neuroimaging genetics has attracted growing attention and interest, which is thought to be a
powerful strategy to examine the influence of genetic variants (ie, single nucleotide …

Integrating brain imaging endophenotypes with GWAS for Alzheimer's disease

KA Knutson, W Pan - Quantitative Biology, 2021 - Wiley Online Library
Background Genome wide association studies (GWAS) have identified many genetic
variants associated with increased risk of Alzheimer's disease (AD). These susceptibility loci …

[HTML][HTML] Brain-wide genome-wide colocalization study for integrating genetics, transcriptomics and brain morphometry in Alzheimer's disease

J Bao, J Wen, Z Wen, S Yang, Y Cui, Z Yang, G Erus… - NeuroImage, 2023 - Elsevier
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases.
However, the AD mechanism has not yet been fully elucidated to date, hindering the …

Structural neuroimaging genetics interactions in Alzheimer's disease

SW Moon, ID Dinov, J Kim, A Zamanyan… - Journal of …, 2015 - content.iospress.com
This article investigates late-onset cognitive impairment using neuroimaging and genetics
biomarkers for Alzheimer's Disease Neuroimaging Initiative (ADNI) participants. Eight …

[HTML][HTML] Multimodal brain imaging reveals structural differences in Alzheimer's disease polygenic risk carriers: a study in healthy young adults

SF Foley, KE Tansey, X Caseras, T Lancaster… - Biological …, 2017 - Elsevier
Background Recent genome-wide association studies have identified genetic loci that jointly
make a considerable contribution to risk of developing Alzheimer's disease (AD). Because …

Network-based analysis of genetic variants associated with hippocampal volume in Alzheimer's disease: a study of ADNI cohorts

A Song, J Yan, S Kim, SL Risacher, AK Wong… - BioData mining, 2016 - Springer
Background Alzheimer's disease (AD) is a neurodegenerative disease that causes
dementia. While molecular basis of AD is not fully understood, genetic factors are expected …

Genetic study of multimodal imaging Alzheimer's disease progression score implicates novel loci

MA Scelsi, RR Khan, M Lorenzi, L Christopher… - Brain, 2018 - academic.oup.com
Identifying genetic risk factors underpinning different aspects of Alzheimer's disease has the
potential to provide important insights into pathogenesis. Moving away from simple case …

[HTML][HTML] Multimodal analysis of disease onset in Alzheimer's disease using Connectome, Molecular, and genetics data

S Oh, S Kim, J Lee, B Park, JH Won, H Park - NeuroImage: Clinical, 2024 - Elsevier
Alzheimer's disease (AD) and its related age at onset (AAO) are highly heterogeneous, due
to the inherent complexity of the disease. They are affected by multiple factors, such as …