Placental lipoprotein lipase (LPL) is crucial for placental lipid transfer. Impaired LPL gene
expression and activity were reported in pregnancies complicated by gestational diabetes …

Gestational diabetes mellitus (GDM) is associated with obesity in childhood. This suggests
that consequences of in utero exposure to maternal hyperglycemia extend beyond the fetal …

Introduction Recent data suggest that in addition to glucose, fetal growth is related to
maternal triglycerides (TG). To reach the fetus, TG must be hydrolyzed to free fatty acids …

Maternal hypertriglyceridemia is a normal condition in late gestation and is an adaptation to
ensure an adequate nutrient supply to the fetus. Placental lipoprotein lipase (LPL) is …

Maternal diabetes can cause fetal macrosomia and increased risk of obesity, diabetes, and
cardiovascular disease in adulthood of the offspring. Although increased transplacental lipid …

Infants of women with gestational diabetes mellitus (GDM) are more likely to be born large
for gestational age with a higher percentage body fat. Elevated maternal lipids may …

Aims/Hypothesis We hypothesized that diabetes during pregnancy (DDP) alters genome-
wide DNA methylation in placenta resulting in differentially methylated loci of metabolically …

Emerging evidences indicate that placenta plays a critical role in gestational diabetes
mellitus (GDM). DNA methylation could be associated with altered placental development …

The fetal demand for FFA increases as gestation proceeds, and LPL represents one
potential mechanism for increasing placental lipid transport. We examined LPL activity and …

Intrauterine growth restriction (IUGR) is associated with reduced placental supply of
nutrients to the fetus. Lipoprotein lipase (LPL) mediates the hydrolysis of triglycerides from …