Placental and cord blood methylation of genes involved in energy homeostasis: association with fetal growth and neonatal body composition
M Díaz, C García, G Sebastiani, F de Zegher… - Diabetes, 2017 - Am Diabetes Assoc
Low weight at birth is associated with subsequent susceptibility to diabetes. Epigenetic
modulation is among the mechanisms potentially mediating this association. We performed …
modulation is among the mechanisms potentially mediating this association. We performed …
Effects of obesity and gestational diabetes mellitus on placental phospholipids
Gestational diabetes mellitus (GDM) is associated with adverse effects in the offspring. The
composition of placental glycerophospholipids (GPL) is known to be altered in GDM and …
composition of placental glycerophospholipids (GPL) is known to be altered in GDM and …
Cord blood DNA methylation of immune and lipid metabolism genes is associated with maternal triglycerides and child adiposity
Objective Fetal exposures may impact offspring epigenetic signatures and adiposity. The
authors hypothesized that maternal metabolic traits associate with cord blood DNA …
authors hypothesized that maternal metabolic traits associate with cord blood DNA …
Maternal obesity and gestational diabetes are associated with placental leptin DNA methylation
Objective In this study, we aimed to investigate relationships between maternal
prepregnancy obesity and gestational diabetes mellitus and placental leptin DNA …
prepregnancy obesity and gestational diabetes mellitus and placental leptin DNA …
Association of pre‐eclampsia with common coding sequence variations in the lipoprotein lipase gene
CA Hubel, JM Roberts, RE Ferrell - Clinical genetics, 1999 - Wiley Online Library
Marked dyslipidemia may contribute to endothelial cell dysfunction in pre‐eclampsia.
Carriers of N291S or D9N missense mutations in the lipoprotein lipase (LPL) gene exhibit …
Carriers of N291S or D9N missense mutations in the lipoprotein lipase (LPL) gene exhibit …
Maternal BMI and gestational diabetes alter placental lipid transporters and fatty acid composition
MT Segura, H Demmelmair, S Krauss-Etschmann… - Placenta, 2017 - Elsevier
Introduction Placental fatty acid (FA) uptake and metabolism depend on maternal supply
which may be altered when women have a high pre-pregnancy body mass index (BMI) or …
which may be altered when women have a high pre-pregnancy body mass index (BMI) or …
Epigenetic marks associated with gestational diabetes mellitus across two time points during pregnancy
T Linares-Pineda, N Peña-Montero… - Clinical …, 2023 - Springer
An adverse intrauterine or periconceptional environment, such as hyperglycemia during
pregnancy, can affect the DNA methylation pattern both in mothers and their offspring. In this …
pregnancy, can affect the DNA methylation pattern both in mothers and their offspring. In this …
Maternal high-fat feeding increases placental lipoprotein lipase activity by reducing SIRT1 expression in mice
L Qiao, Z Guo, C Bosco, S Guidotti, Y Wang… - Diabetes, 2015 - Am Diabetes Assoc
This study investigated how maternal overnutrition and obesity regulate expression and
activation of proteins that facilitate lipid transport in the placenta. To create a maternal …
activation of proteins that facilitate lipid transport in the placenta. To create a maternal …
A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health
N Fernandez-Jimenez, R Fore, A Cilleros-Portet… - Communications …, 2022 - nature.com
Higher maternal pre-pregnancy body mass index (ppBMI) is associated with increased
neonatal morbidity, as well as with pregnancy complications and metabolic outcomes in …
neonatal morbidity, as well as with pregnancy complications and metabolic outcomes in …
Comprehensive analysis of preeclampsia-associated DNA methylation in the placenta
T Chu, K Bunce, P Shaw, V Shridhar, A Althouse… - PloS one, 2014 - journals.plos.org
Background A small number of recent reports have suggested that altered placental DNA
methylation may be associated with early onset preeclampsia. It is important that further …
methylation may be associated with early onset preeclampsia. It is important that further …