Placental and cord blood methylation of genes involved in energy homeostasis: association with fetal growth and neonatal body composition

M Díaz, C García, G Sebastiani, F de Zegher… - Diabetes, 2017 - Am Diabetes Assoc
Low weight at birth is associated with subsequent susceptibility to diabetes. Epigenetic
modulation is among the mechanisms potentially mediating this association. We performed …

Effects of obesity and gestational diabetes mellitus on placental phospholipids

O Uhl, H Demmelmair, MT Segura, J Florido… - Diabetes research and …, 2015 - Elsevier
Gestational diabetes mellitus (GDM) is associated with adverse effects in the offspring. The
composition of placental glycerophospholipids (GPL) is known to be altered in GDM and …

Cord blood DNA methylation of immune and lipid metabolism genes is associated with maternal triglycerides and child adiposity

SW Waldrop, S Niemiec, C Wood, LE Gyllenhammer… - …, 2024 - Wiley Online Library
Objective Fetal exposures may impact offspring epigenetic signatures and adiposity. The
authors hypothesized that maternal metabolic traits associate with cord blood DNA …

Maternal obesity and gestational diabetes are associated with placental leptin DNA methylation

C Lesseur, DA Armstrong, AG Paquette, Z Li… - American journal of …, 2014 - Elsevier
Objective In this study, we aimed to investigate relationships between maternal
prepregnancy obesity and gestational diabetes mellitus and placental leptin DNA …

Association of pre‐eclampsia with common coding sequence variations in the lipoprotein lipase gene

CA Hubel, JM Roberts, RE Ferrell - Clinical genetics, 1999 - Wiley Online Library
Marked dyslipidemia may contribute to endothelial cell dysfunction in pre‐eclampsia.
Carriers of N291S or D9N missense mutations in the lipoprotein lipase (LPL) gene exhibit …

Maternal BMI and gestational diabetes alter placental lipid transporters and fatty acid composition

MT Segura, H Demmelmair, S Krauss-Etschmann… - Placenta, 2017 - Elsevier
Introduction Placental fatty acid (FA) uptake and metabolism depend on maternal supply
which may be altered when women have a high pre-pregnancy body mass index (BMI) or …

Epigenetic marks associated with gestational diabetes mellitus across two time points during pregnancy

T Linares-Pineda, N Peña-Montero… - Clinical …, 2023 - Springer
An adverse intrauterine or periconceptional environment, such as hyperglycemia during
pregnancy, can affect the DNA methylation pattern both in mothers and their offspring. In this …

Maternal high-fat feeding increases placental lipoprotein lipase activity by reducing SIRT1 expression in mice

L Qiao, Z Guo, C Bosco, S Guidotti, Y Wang… - Diabetes, 2015 - Am Diabetes Assoc
This study investigated how maternal overnutrition and obesity regulate expression and
activation of proteins that facilitate lipid transport in the placenta. To create a maternal …

A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health

N Fernandez-Jimenez, R Fore, A Cilleros-Portet… - Communications …, 2022 - nature.com
Higher maternal pre-pregnancy body mass index (ppBMI) is associated with increased
neonatal morbidity, as well as with pregnancy complications and metabolic outcomes in …

Comprehensive analysis of preeclampsia-associated DNA methylation in the placenta

T Chu, K Bunce, P Shaw, V Shridhar, A Althouse… - PloS one, 2014 - journals.plos.org
Background A small number of recent reports have suggested that altered placental DNA
methylation may be associated with early onset preeclampsia. It is important that further …