DNA methylation trajectories during pregnancy
O Gruzieva, SK Merid, S Chen… - Epigenetics …, 2019 - journals.sagepub.com
There is emerging evidence on DNA methylation (DNAm) variability over time; however, little
is known about dynamics of DNAm patterns during pregnancy. We performed an epigenome …
is known about dynamics of DNAm patterns during pregnancy. We performed an epigenome …
Associations of maternal early-pregnancy blood glucose and insulin concentrations with DNA methylation in newborns
ML Geurtsen, VWV Jaddoe, R Gaillard, JF Felix - Clinical epigenetics, 2020 - Springer
Background Intrauterine exposure to a disturbed maternal glucose metabolism is associated
with adverse offspring outcomes. DNA methylation is a potential mechanism underlying …
with adverse offspring outcomes. DNA methylation is a potential mechanism underlying …
Prenatal growth patterns and birthweight are associated with differential DNA methylation and gene expression of cardiometabolic risk genes in human placentas: a …
Inherent genetic programming and environmental factors affect fetal growth in utero.
Epidemiologic data in growth-altered fetuses, either intrauterine growth restricted (IUGR) or …
Epidemiologic data in growth-altered fetuses, either intrauterine growth restricted (IUGR) or …
Lipoprotein concentrations in newborns are associated with allelic variations in their mothers
OS Descamps, M Bruniaux, PF Guilmot, R Tonglet… - Atherosclerosis, 2004 - Elsevier
Background: Factors determining lipoprotein concentrations in the fetus are not yet fully
understood. We postulated that an important factor is the genetic make-up of the mother. In …
understood. We postulated that an important factor is the genetic make-up of the mother. In …
Genetic variation at the hormone sensitive lipase: gender‐specific association with plasma lipid and glucose concentrations
L Qi, H Shen, I Larson, JR Barnard… - Clinical …, 2004 - Wiley Online Library
Hormone‐sensitive lipase (HSL) catalyzes the intracellular hydrolysis of triacylglycerols and
cholesteryl esters, and it is involved in regulating body fat, steroidogenesis, and insulin …
cholesteryl esters, and it is involved in regulating body fat, steroidogenesis, and insulin …
Early pregnancy maternal blood DNA methylation in repeat pregnancies and change in gestational diabetes mellitus status—a pilot study
DA Enquobahrie, A Moore, S Muhie… - Reproductive …, 2015 - journals.sagepub.com
Repeat pregnancies with different perinatal outcomes minimize underlying maternal genetic
diversity and provide unique opportunities to investigate nongenetic risk factors and …
diversity and provide unique opportunities to investigate nongenetic risk factors and …
Methylation levels at IGF2 and GNAS DMRs in infants born to preeclamptic pregnancies
J He, A Zhang, M Fang, R Fang, J Ge, Y Jiang… - BMC genomics, 2013 - Springer
Background Offspring of pregnancy complicated with preeclampsia are at high risk for
hypertension, stroke and possibly obesity. The mechanisms behind the association of …
hypertension, stroke and possibly obesity. The mechanisms behind the association of …
Altered methylation and expression patterns of genes regulating placental angiogenesis in preterm pregnancy
DP Sundrani, US Reddy… - Reproductive …, 2014 - journals.sagepub.com
Introduction: Altered angiogenesis has been implicated in the pathogenesis of various
pregnancy complications, particularly preeclampsia. At present, there is a lack of data on the …
pregnancy complications, particularly preeclampsia. At present, there is a lack of data on the …
Association between single-nucleotide polymorphisms in the endothelial lipase (LIPG) gene and high-density lipoprotein cholesterol levels
AR Mank-Seymour, KL Durham, JF Thompson… - … et Biophysica Acta (BBA …, 2004 - Elsevier
Endothelial lipase (LIPG) is the latest addition to the triglyceride lipase family of genes that
includes pancreatic lipase (PL), hepatic lipase (HL), and lipoprotein lipase (LPL). These …
includes pancreatic lipase (PL), hepatic lipase (HL), and lipoprotein lipase (LPL). These …
Maternal glucose and LDL-cholesterol levels are related to placental leptin gene methylation, and, together with nutritional factors, largely explain a higher methylation …
Background Leptin, mainly secreted by fat cells, plays a core role in the regulation of
appetite and body weight, and has been proposed as a mediator of metabolic programming …
appetite and body weight, and has been proposed as a mediator of metabolic programming …