There is emerging evidence on DNA methylation (DNAm) variability over time; however, little
is known about dynamics of DNAm patterns during pregnancy. We performed an epigenome …

Background Intrauterine exposure to a disturbed maternal glucose metabolism is associated
with adverse offspring outcomes. DNA methylation is a potential mechanism underlying …

Inherent genetic programming and environmental factors affect fetal growth in utero.
Epidemiologic data in growth-altered fetuses, either intrauterine growth restricted (IUGR) or …

Background: Factors determining lipoprotein concentrations in the fetus are not yet fully
understood. We postulated that an important factor is the genetic make-up of the mother. In …

Hormone‐sensitive lipase (HSL) catalyzes the intracellular hydrolysis of triacylglycerols and
cholesteryl esters, and it is involved in regulating body fat, steroidogenesis, and insulin …

Repeat pregnancies with different perinatal outcomes minimize underlying maternal genetic
diversity and provide unique opportunities to investigate nongenetic risk factors and …

Background Offspring of pregnancy complicated with preeclampsia are at high risk for
hypertension, stroke and possibly obesity. The mechanisms behind the association of …

Introduction: Altered angiogenesis has been implicated in the pathogenesis of various
pregnancy complications, particularly preeclampsia. At present, there is a lack of data on the …

Endothelial lipase (LIPG) is the latest addition to the triglyceride lipase family of genes that
includes pancreatic lipase (PL), hepatic lipase (HL), and lipoprotein lipase (LPL). These …

Background Leptin, mainly secreted by fat cells, plays a core role in the regulation of
appetite and body weight, and has been proposed as a mediator of metabolic programming …