Transcription factors (TFs) specifically bind to DNA, recruit cofactor proteins and modulate
target gene expression, rendering them essential roles in the regulation of numerous …

Transcription factors (TFs) represent key biological players in diseases including cancer,
autoimmunity, diabetes and cardiovascular disease. However, outside nuclear receptors …

Highlights•Transcription factors are generally dysregulated in tumors.•Most oncogenic
transcription factors are considered as “undruggable” targets.•Post-translational …

Transcription factors (TFs) orchestrate multiple cellular processes through tight regulation
via post-translational modifications (PTMs). Thus, decoding the combinations of PTMs …

Transcription factors (TFs) are commonly deregulated in the pathogenesis of human cancer
and are a major class of cancer cell dependencies. Consequently, targeting of TFs can be …

Dysregulation or mutation of DNA binding proteins such as transcription factors (TFs) is
associated with the onset and progression of various types of disease, including cancer …

Many drugs, both approved and in development, exert their effects through transcription
factors. The complexity of the biology of transcriptional regulation, however, presents …

Immune function is highly controlled at the transcriptional level by the binding of transcription
factors (TFs) to promoter and enhancer elements. Several TF families play major roles in …

Abstract Background Transcription factors (TFs), the key players in transcriptional regulation,
have attracted great experimental attention, yet the functions of most human TFs remain …

Transcription factors play an important role in the long-term regulation of cell growth,
differentiation and responses to environmental cues. There is growing evidence that these …