Recent experiments have shown that the Taiwan mutation (D7H) slows the fibril formation of
amyloid peptides Aβ40 and Aβ42. Motivated by this finding, we have studied the influence of …

Single amino acid mutations in amyloid-beta (Aβ) peptides can lead to early onset and
increased severity of Alzheimer's disease. An example is the Osaka mutation (Aβ1 …

To study the early stage of amyloid‐β peptide (Aβ) aggregation, hexamers of the wild‐type
(WT) Aβ16–35 and its mutants with amyloid‐like conformations have been studied by …

Using replica exchange molecular dynamics, we study the effect of Asp23Tyr mutation on
Aβ10− 40 fibril growth. The effect of this mutation is revealed through the computation of free …

Effects of amyloid beta (Aβ) peptide Aβ 40 on secondary structures of Aβ 42 are studied by
all-atom simulations using the GROMOS96 43a1 force field with explicit water. It is shown …

The self-assembly of the amyloid beta (Aβ) peptides into senile plaques is the hallmark of
Alzheimer's disease. Recent experiments have shown that the English familial disease …

Aggregation of amyloid β-proteins (Aβ) plays a key role in the mechanism of molecular
pathogenesis of Alzheimer's disease (AD). It is known that full-length Aβ (1–42) is more …

Recent experiments have shown that the congener Aβ1− 40 [D23− K28], in which the side
chains of charged residues Asp23 and Lys28 are linked by a lactam bridge, forms amyloid …

Understanding the key factors that govern the rate of protein aggregation is of immense
interest since protein aggregation is associated with a number of neurodegenerative …

The aim of this work is to investigate the effects of different force fields and temperatures on
the structural character of Aβ (12–28) peptide in aqueous solution. Moreover, the structural …