Cellular stress responses influence cell fate decisions. Apoptosis and proliferation represent
opposing reactions to cellular stress or damage and may influence distinct health outcomes …

In 1960, Rita Levi-Montalcini and Barbara Booker made an observation that transformed
neuroscience: as neurons mature, they become apoptosis resistant. The following year …

The term cellular senescence was introduced more than five decades ago to describe the
state of growth arrest observed in aging cells. Since this initial discovery, the phenotypes …

Along with a general decline in overall health, most chronic degenerative human diseases
are inherently associated with increasing age. Age-associated cognitive impairments and …

Aging is inevitable. Along with reduced ability to maintain the homeostasis of various
biological processes, aging gradually deteriorates overall health. Extensive research on the …

Increased life expectancies have significantly increased the number of individuals suffering
from geriatric neurodegenerative diseases such as Alzheimer's disease (AD) and …

Significance: Cell senescence was originally defined by an acute loss of replicative capacity
and thus believed to be restricted to proliferation-competent cells. More recently …

SnapShot: Cellular Senescence in Pathophysiology Page 1 Lysosomal activity SASP SASP
Immune surveillance Cellular plasticity/ tissue regeneration Cellular plasticity/tissue regeneration …

Cellular senescence is a state of terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory phenotype. In the brain, senescent cells …

Cellular senescence is the arrest of normal cell division. Oncogenic genes and oxidative
stress, which cause genomic DNA damage and generation of reactive oxygen species, lead …