Candesartan and epigallocatechin‐3‐gallate ameliorate gentamicin‐induced renal damage in rats through p38‐MAPK and NF‐κB pathways

HI Ahmed, EA Mohamed - Journal of biochemical and …, 2019 - Wiley Online Library
This study pointed to estimate the possible protective impacts of candesartan and/or
epigallocatechin‐3‐gallate (EGCG) against gentamicin‐induced nephrotoxicity. The current …

Gentisic acid mitigates gentamicin-induced nephrotoxicity in rats

M Saeedavi, M Goudarzi, I Fatemi, Z Basir, SMA Noori… - Tissue and Cell, 2023 - Elsevier
The current investigation was considered to evaluate the beneficial effects of gentisic acid
(GA) on gentamicin (GEN)-induced nephrotoxicity in rat kidneys through assessment of …

Exogenous glutathione protects against gentamicin-induced acute kidney injury by inhibiting NF-κB pathway, oxidative stress, and apoptosis and regulating PCNA

E Babaeenezhad, O Dezfoulian… - Drug and Chemical …, 2023 - Taylor & Francis
This study was designed, for the first time, to examine the possible nephroprotective effects
of exogenous glutathione (EGSH)(100 mg/kg, intraperitoneally) on gentamicin-induced …

Involvement of oxidative stress and toll-like receptor-4 signaling pathways in gentamicin-induced nephrotoxicity in male Sprague Dawley rats

Z Pakfetrat, S Janfeshan, F Masjedi… - Drug and Chemical …, 2022 - Taylor & Francis
Gentamicin (GM) is an antibiotic belonging to an aminoglycoside family that might induce
nephrotoxicity in human and animal models via oxidative stress. Toll-like receptors (TLRs) …

Angiotensin II receptor blocker, losartan, ameliorates gentamicin-induced oxidative stress and nephrotoxicity in rats

GH Heeba - Pharmacology, 2011 - karger.com
Abstract Background/Aims: This study investigates the ameliorative effect of concurrent and
pretreatment with angiotensin II receptor blocker, losartan (LOS), against gentamicin (GEN) …

Atorvastatin prevents gentamicin-induced renal damage in rats through the inhibition of p38-MAPK and NF-kB pathways

E Ozbek, M Cekmen, YO Ilbey, A Simsek, EC Polat… - Renal failure, 2009 - Taylor & Francis
Background and aims. Gentamicin (GM) is still considered to be an important antibiotic
against life-threatening, gram-negative bacterial infections despite its known nephrotoxic …

[HTML][HTML] Thymoquinone and curcumin attenuate gentamicin-induced renal oxidative stress, inflammation and apoptosis in rats

AM Mahmoud, OM Ahmed, SR Galaly - EXCLI journal, 2014 - ncbi.nlm.nih.gov
The present study was aimed to investigate the possible protective effects of thymoquinone
(TQ) and curcumin (Cur) on gentamicin (GM)-induced nephrotoxicity in rats. Rats were …

Protective effect of naringenin against gentamicin-induced nephrotoxicity in rats

AA Fouad, WH Albuali, A Zahran, W Gomaa - … toxicology and pharmacology, 2014 - Elsevier
The protective effect of naringenin, a flavonoid compound isolated from citrus fruits, was
investigated against nephrotoxicity induced by gentamicin (80 mg kg− 1/day, ip, for eight …

[PDF][PDF] Pomegranate attenuates acute gentamicin-induced nephrotoxicity in Sprague-Dawley rats: The potential antioxidant and anti-inflammatory effects

HM Al-Kuraishy, A Al-Gareeb, MSS Al-Naimi - Pomegranate, 2019 - academia.edu
Objectives: Nephrotoxicity is a renal-specific situation in which the excretion of toxic
metabolites is reduced due to toxic agents and drugs. Gentamicin is an antibiotic belongs to …

Apigenin attenuates molecular, biochemical, and histopathological changes associated with renal impairments induced by gentamicin exposure in rats

MM Hussein, HA Althagafi, F Alharthi… - … Science and Pollution …, 2022 - Springer
Gentamicin (GM) is an aminoglycoside antibiotic used to treat bacterial infections. However,
its application is accompanied by renal impairments. Apigenin is a flavonoid found in many …