Epitope spreading of autoantibody response to PLA2R associates with poor prognosis in membranous nephropathy

B Seitz-Polski, G Dolla, C Payré… - Journal of the …, 2016 - journals.lww.com
The phospholipase A2 receptor (PLA2R1) is the major autoantigen in idiopathic
membranous nephropathy. However, the value of anti-PLA2R1 antibody titers in predicting …

Clinical relevance of domain-specific phospholipase A2 receptor 1 antibody levels in patients with membranous nephropathy

L Reinhard, G Zahner, S Menzel… - Journal of the …, 2020 - journals.lww.com
Background Antibodies against phospholipase A 2 receptor 1 (PLA 2 R1) are found in 80%
of patients with membranous nephropathy, and previous studies described three …

Phospholipase A2 receptor 1 epitope spreading at baseline predicts reduced likelihood of remission of membranous nephropathy

B Seitz-Polski, H Debiec, A Rousseau… - Journal of the …, 2018 - journals.lww.com
The phospholipase A2 receptor (PLA2R1) is the major autoantigen in primary membranous
nephropathy. Several PLA2R1 epitopes have been characterized, and a retrospective study …

Identification of the immunodominant epitope region in phospholipase A2 receptor-mediating autoantibody binding in idiopathic membranous nephropathy

L Kao, V Lam, M Waldman, RJ Glassock… - Journal of the American …, 2015 - journals.lww.com
Membranous nephropathy (MN) is a common cause of nephrotic syndrome in adults. Recent
clinical studies established that> 70% of patients with idiopathic (also called primary) MN …

Identification of a major epitope recognized by PLA2R autoantibodies in primary membranous nephropathy

M Fresquet, TA Jowitt, J Gummadova… - Journal of the …, 2015 - journals.lww.com
Abstract Phospholipase A 2 receptor 1 (PLA2R) is a target autoantigen in 70% of patients
with idiopathic membranous nephropathy. We describe the location of a major epitope in the …

Phospholipase A2 receptor (PLA2R1) sequence variants in idiopathic membranous nephropathy

MJH Coenen, JM Hofstra, H Debiec… - Journal of the …, 2013 - journals.lww.com
The M-type receptor for phospholipase A2 (PLA2R1) is the major target antigen in idiopathic
membranous nephropathy (iMN). Our recent genome-wide association study showed that …

[HTML][HTML] Anti-PLA2R antibodies measured by ELISA predict long-term outcome in a prevalent population of patients with idiopathic membranous nephropathy

D Kanigicherla, J Gummadova, EA McKenzie… - Kidney international, 2013 - Elsevier
Antibodies to the phospholipase A2 receptor 1 (PLA2R1) have been reported in 70% of
cases of idiopathic membranous nephropathy (IMN). The genetic susceptibility of IMN has …

Prognostic value of PLA2R autoimmunity detected by measurement of anti-PLA2R antibodies combined with detection of PLA2R antigen in membranous nephropathy …

F Pourcine, K Dahan, F Mihout, M Cachanado… - PloS one, 2017 - journals.plos.org
Introduction Clinical course of membranous nephropathy (MN) is difficult to predict.
Measurement of circulating anti-PLA2R autoantibodies (PLA2R-Ab) and detection in …

Anti-PLA2R antibodies as a prognostic factor in PLA2R-related membranous nephropathy

SA Timmermans, MA Abdul Hamid… - American journal of …, 2015 - karger.com
Background: The natural course of idiopathic membranous nephropathy (MN) varies, as it is
known through favorable outcomes in most patients. However, one third of patients with …

Antiphospholipase A2 receptor antibody titer and subclass in idiopathic membranous nephropathy

JM Hofstra, H Debiec, CD Short, T Pellé… - Journal of the …, 2012 - journals.lww.com
The phospholipase A 2 receptor (PLA 2 R) is the major target antigen in idiopathic
membranous nephropathy. The technique for measuring antibodies against PLA 2 R and …