Therapeutic strategies for hepatitis B virus infection: towards a cure

GC Fanning, F Zoulim, J Hou, A Bertoletti - Nature reviews Drug …, 2019 - nature.com
Chronic hepatitis B virus (HBV) infection is a common cause of liver disease globally, with a
disproportionately high burden in South-East Asia. Vaccines and nucleoside or nucleotide …

Taraxacum mongolicum extract exhibits a protective effect on hepatocytes and an antiviral effect against hepatitis B virus in animal and human cells

YY Jia, RF Guan, YH Wu, XP Yu… - Molecular …, 2014 - spandidos-publications.com
In order to validate the antiviral effect against hepatitis B virus (HBV) of Taraxacum
mongolicum (T. mongolicum), the protective effect on hepatocytes, and antiviral properties …

[HTML][HTML] Inhibition of hepatitis B virus production by Boehmeria nivea root extract in HepG2 2.2. 15 cells

KL Huang, YK Lai, CC Lin… - World Journal of …, 2006 - ncbi.nlm.nih.gov
AIM: To explore the anti-hepatitis B virus (HBV) effects of Boehmeria nivea (B. nivea) root
extract (BNE) by using the HepG2 2.2. 15 cell model system. METHODS: Hepatitis B surface …

Anti-hepatitis B virus effect of matrine-type alkaloid and involvement of p38 mitogen-activated protein kinase and tumor necrosis factor receptor-associated factor 6

JX Chen, HH Shen, M Niu, YM Guo, XQ Liu, YZ Han… - Virus research, 2016 - Elsevier
The matrine-type alkaloid, oxymatrine inhibits hepatitis B virus (HBV) replication but very
little is known about these effects in other matrine-type alkaloids, including sophoridine and …

A novel tricyclic polyketide, vanitaracin A, specifically inhibits the entry of hepatitis B and D viruses by targeting sodium taurocholate cotransporting polypeptide

M Kaneko, K Watashi, S Kamisuki… - Journal of …, 2015 - Am Soc Microbiol
Anti-hepatitis B virus (HBV) drugs are currently limited to nucleos (t) ide analogs (NAs) and
interferons. A challenge of drug development is the identification of small molecules that …

Inhibitory effect of Phyllanthus urinaria L. extract on the replication of lamivudine-resistant hepatitis B virus in vitro

J Jung, NK Kim, S Park, HJ Shin, SG Hwang… - BMC complementary and …, 2015 - Springer
Background Long-term treatment of chronic hepatitis B (CHB) with nucleos (t) ide analogs
results in the emergence of drug-resistant hepatitis B virus (HBV) harboring mutations in the …

A review of non-nucleoside anti-hepatitis B virus agents

F Zhang, G Wang - European journal of medicinal chemistry, 2014 - Elsevier
Hepatitis B Virus is the most common cause of chronic liver disease worldwide. Currently
approved agents of chronic HBV infection treatment include interferon and nucleoside …

The Anti‐Hepatitis B Virus Activity of Boehmeria nivea Extract in HBV‐Viremia SCID Mice

JM Chang, KL Huang, TTT Yuan… - Evidence‐Based …, 2010 - Wiley Online Library
Boehmeria nivea extract (BNE) is widely used in southern Taiwan as a folk medicine for
hepato‐protection and hepatitis treatment. In previous studies, we demonstrated that BNE …

Plant-derived antivirals against hepatitis c virus infection

ACG Jardim, JF Shimizu, P Rahal, M Harris - Virology journal, 2018 - Springer
Hepatitis C virus (HCV) infection is a worldwide public health burden and it is estimated that
185 million people are or have previously been infected worldwide. There is no effective …

Selective hepatitis B and D virus entry inhibitors from the group of pentacyclic lupane-type betulin-derived triterpenoids

M Kirstgen, KAAT Lowjaga, SF Müller, N Goldmann… - Scientific Reports, 2020 - nature.com
Current treatment options against hepatitis B and D virus (HBV/HDV) infections have only
limited curative effects. Identification of Na+/taurocholate co-transporting polypeptide …