Dear Editor, Bile acids are a group of cholesterol-derived physiological surfactants required
for digestion of lipids and fat-soluble vitamins. 1 However, excess of bile acids is detrimental …

Dear Editor, Bile is a complex aqueous secretion produced by the liver that facilitates the
digestion of lipids in the small intestine. A group of ATP binding cassette (ABC) transporters …

Bile salt export pump (BSEP) adenosine triphosphate–binding cassette B11 (ABCB11) is a
liver‐specific ABC transporter that mediates canalicular bile salt excretion from hepatocytes …

ABCB11 is responsible for biliary bile acid secretion at the canalicular membrane of
hepatocytes. Variations in the ABCB11 gene cause a spectrum of rare liver diseases. The …

The bile salt export pump (BSEP) encoded by ABCB11 is located in the canalicular
membrane of hepatocytes and mediates the secretion of numerous conjugated bile salts into …

The bile salt export pump (BSEP, ABCB11) is the primary transporter of bile acids from the
hepatocyte to the biliary system. This rate-limiting step in bile formation is essential to the …

BACKGROUND/AIMS: Inherited dysfunction of the bile salt export pump BSEP (ABCB11)
causes a progressive and a benign form of familial intrahepatic cholestasis, denominated as …

The bile salt export pump, encoded by ABCB11, is the predominant canalicular transport
protein for biliary bile acid secretion. The level of ABCB11 expression in humans is widely …

ATP‐binding cassette (ABC) transporters are the members of the efflux pumps that are
responsible for the removal of cytotoxic substances by active transport. ABCB11, the bile salt …

Abstract Background & Aims The bile salt export pump (BSEP, ABCB 11) is essential for bile
salt secretion at the canalicular membrane of liver cells. Clinical phenotypes associated with …