Solid tumors consist of several components, including normal and stromal cells, extracellular
matrix, and vasculature. To grow and metastasize, tumors must stimulate the development of …

Judah Folkman recognized that new blood vessel formation is important for tumor growth
and proposed antiangiogenesis as a novel approach to cancer therapy. Discovery of …

Tumors induce angiogenesis to acquire oxygen and nutrition from their adjacent
microenvironment. Tumor angiogenesis has been believed to be induced primarily by the …

Vascular endothelial growth factor (VEGF) dependent tumor angiogenesis is an essential
step for the initiation and promotion of tumor progression. The hypothesis that VEGF-driven …

New vessel formation (angiogenesis) is an essential physiological process for embryologic
development, normal growth, and tissue repair. Angiogenesis is tightly regulated at the …

Tumors undergo fast neovascularization to support the rapid proliferation of cancer cells.
Vasculature in tumors, unlike that in wound healing, is immature and affects the tumor …

The blood vessels supplying tumors are strikingly heterogeneous and differ from their
normal counterparts with respect to organization, structure, and function. Six distinctly …

Tumoral angiogenesis is necessary for the growth of neoplasms and the production of
metastasis. The vascular endothelial growth factor (VEGF) is a homodimeric heparin-binding …

Several model tumour systems are now known to display increased vascular permeability
compared with normal tissues, permitting their selective targeting using macromolecular …

New blood vessel formation (angiogenesis) is a fundamental event in the process of tumor
growth and metastatic dissemination. Hence, the molecular basis of tumor angiogenesis has …