Psoriasis is an autoimmune skin disease characterized by keratinocyte hyperproliferation
and chronic inflammation. The pathogenesis of psoriasis involves proinflammatory …

To investigate how the CARD14 E138A psoriasis-associated mutation induces skin
inflammation, a knock-in mouse strain was generated that allows tamoxifen-induced …

Background Skin atrophy is a major adverse effect of topical glucocorticoids. We recently
reported that REDD1 (regulated in development and DNA damage 1) and FKBP51 (FK506 …

Background The management of slow or non-healing ulcerations constitutes an increasing
clinical challenge in the developed world because of the ageing of the population and the …

Psoriasis and atopic dermatitis are chronic inflammatory skin diseases characterized by
keratinocyte (KC) hyperproliferation and epidermal acanthosis (hyperplasia). The milieu of …

Cytokines are critical checkpoints of inflammation. The treatment of human autoimmune
disease has been revolutionized by targeting inflammatory cytokines as key drivers of …

Simple Summary PI3K/Akt pathway has an impressive story as tumor marker. PI3K-
dependent solid tumors have been studied for several years in order to inhibit the pathway …

Background In the last years, a clear link between the endocrine signalling also influenced
by Western diet and the pathogenesis of acne has emerged 1, 2. In this context, a crucial …

Obesity is a global epidemic representing a serious public health burden as it is a major risk
factor for the development of cardiovascular disease, stroke and all-cause mortality. Chronic …

Macrophages become activated initiating innate immune responses. Depending on the
signals, macrophages obtain an array of activation phenotypes, described by the broad …