Psoriasis is a chronic inflammatory skin disease that affects approximately 2% of worldwide
population, and causing long-term troubles to the patients. Therefore, it is urgent to develop …

Abstract Phosphatidylinositol 4-kinase (PI4K) is a lipid kinase that can catalyze the transfer
of phosphate group from ATP to the inositol ring of phosphatidylinositol (PtdIns) resulting in …

Transient receptor potential ankyrin 1 (TRPA1), a membrane protein ion channel, is known
to mediate itch and pain in skin. The function of TRPA1, however, in psoriasiform dermatitis …

Background Every day the skin is constantly exposed to several harmful factors that induce
oxidative stress. When the cells are incapable to maintain the balance between antioxidant …

Class 1 Phosphoinositide-3-Kinases (PI3Ks) have been widely studied and mediate
essential roles in cellular proliferation, chemotaxis, insulin sensitivity, and immunity. Here …

Regulatory T cells (Tregs) play fundamental roles in maintaining peripheral tolerance to
prevent autoimmunity and limit legitimate immune responses, a feature hijacked in tumor …

Adaptive immunity is essential for pathogen and tumor eradication, but may also trigger
uncontrolled or pathological inflammation. T cell receptor, co-stimulatory and cytokine …

The systemic inflammatory syndrome concept is one of the foundations that stand at the
basis of revolutionary modern and future therapies, based on the in-depth understanding of …

Inflammation is an evolutionarily conserved host reaction that is initiated in response to
trauma, tissue damage and infection. It leads to changes in tissue homeostasis and blood …

Background: Breast cancer is the predominant form of cancer in women; various cellular
pathways are involved in the initiation and progression of breast cancer. Among the various …