Mice deficient for galanin receptor 2 have decreased neurite outgrowth from adult sensory neurons and impaired pain‐like behaviour
SA Hobson, FE Holmes, NCH Kerr… - Journal of …, 2006 - Wiley Online Library
Expression of the neuropeptide galanin is markedly up‐regulated within the adult dorsal root
ganglia (DRG) following peripheral nerve injury. We have previously demonstrated that …
ganglia (DRG) following peripheral nerve injury. We have previously demonstrated that …
The second galanin receptor GalR2 plays a key role in neurite outgrowth from adult sensory neurons
SA Mahoney, R Hosking, S Farrant… - Journal of …, 2003 - Soc Neuroscience
Expression of the neuropeptide galanin is markedly upregulated within the adult dorsal root
ganglion (DRG) after peripheral nerve injury. We demonstrated previously that the rate of …
ganglion (DRG) after peripheral nerve injury. We demonstrated previously that the rate of …
Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviour
TJS Shi, X Hua, X Lu, S Malkmus… - European Journal of …, 2006 - Wiley Online Library
Galanin is a 29‐amino‐acid peptide expressed in dorsal root ganglion (DRG) neurones and
spinal dorsal horn neurones. It affects pain threshold and has developmental and trophic …
spinal dorsal horn neurones. It affects pain threshold and has developmental and trophic …
Galanin over-expression decreases the development of neuropathic pain-like behaviors in mice after partial sciatic nerve injury
K Hygge-Blakeman, P Brumovsky, JX Hao, XJ Xu… - Brain research, 2004 - Elsevier
The neuropeptide galanin may have a role in modulation of nociception, particularly after
peripheral nerve injury. Here we assessed the development of neuropathic pain-like …
peripheral nerve injury. Here we assessed the development of neuropathic pain-like …
Generation and phenotypic characterization of a galanin overexpressing mouse
K Holmberg, E Kuteeva, P Brumovsky, U Kahl… - Neuroscience, 2005 - Elsevier
In most parts of the peripheral nervous system galanin is expressed at very low levels. To
further understand the functional role of galanin, a mouse overexpressing galanin under the …
further understand the functional role of galanin, a mouse overexpressing galanin under the …
Transgenic overexpression of galanin in the dorsal root ganglia modulates pain-related behavior
FE Holmes, A Bacon, RJP Pope… - Proceedings of the …, 2003 - National Acad Sciences
The neuropeptide galanin is expressed in the dorsal root ganglia (DRG) and spinal cord and
is thought to be involved in the modulation of pain processing. However, its mechanisms of …
is thought to be involved in the modulation of pain processing. However, its mechanisms of …
Transgenic over-expression of galanin in injured primary sensory neurons
A Bacon, FE Holmes, CJ Small, M Ghatei… - …, 2002 - journals.lww.com
The 29 amino acid neuropeptide galanin is normally expressed in< 5% of sensory neurons
in the adult dorsal root ganglia. After nerve transection (axotomy), the galanin content of the …
in the adult dorsal root ganglia. After nerve transection (axotomy), the galanin content of the …
The participation of galanin in pain processing at the spinal level
Abstract Galanin, a 29-amino-acid peptide expressed in dorsal root ganglia (DRG) and
spinal dorsal horn interneurones, is regulated by nerve injury and peripheral inflammation …
spinal dorsal horn interneurones, is regulated by nerve injury and peripheral inflammation …
Galanin knockout mice reveal nociceptive deficits following peripheral nerve injury
BJ Kerr, WBJ Cafferty, YIK Gupta… - European Journal of …, 2000 - Wiley Online Library
The neuropeptide galanin has been identified as a potential neurotransmitter/
neuromodulator within the central nervous system. In the present study, the role of …
neuromodulator within the central nervous system. In the present study, the role of …
Targeted disruption of the galanin gene reduces the number of sensory neurons and their regenerative capacity
FE Holmes, S Mahoney, VR King… - Proceedings of the …, 2000 - National Acad Sciences
The neuropeptide galanin is expressed developmentally in the dorsal root ganglion (DRG)
and is rapidly up-regulated 120-fold after peripheral nerve section in the adult. Here we …
and is rapidly up-regulated 120-fold after peripheral nerve section in the adult. Here we …
相关搜索
- galanin receptor neurite outgrowth
- galanin receptor knockout mice
- galanin receptor galr2
- galanin gene number of sensory neurons
- targeted disruption number of sensory neurons
- nerve injury behaviors in mice
- nerve injury nociceptive deficits
- transgenic overexpression root ganglia
- spinal level pain processing
- galanin gene targeted disruption
- pain behaviour knockout mice