Accumulation of amyloid-β peptide (Aβ) is a pathological hallmark of Alzheimer's disease
(AD). We have previously demonstrated that electrophysiological and neurotoxic effects of …

Alzheimer's disease (AD) is characterized by accumulation of amyloid-β peptide (Aβ) in the
brain regions that subserve memory and cognition. The amylin receptor is a potential target …

Introduction Amylin receptor serves as a portal for the expression of deleterious effects of
amyloid β-protein (Aβ), a key pathologic hallmark of Alzheimer's disease. Previously, we …

Amylin is a metabolic peptide hormone that is co-secreted with insulin from beta cells in the
pancreas and activates many of the downstream targets of insulin. To investigate the …

Background: Amylin, a pancreatic amyloid peptide involved in energy homeostasis, is
increasingly studied in the context of Alzheimer's disease (AD) etiology. To date, conflicting …

Accumulation of amyloid β-peptides (Aβ) in the brain has been linked with memory loss in
Alzheimer's disease and its animal models. However, the synaptic mechanism by which Aβ …

Alzheimer's disease (AD) is a progressive and most frequently diagnosed
neurodegenerative disorder. However, there is still no drug preventing the progress of this …

Beta-amyloid peptide (Aβ) has a causal role in the pathophysiology of Alzheimer's disease
(AD). Recent studies indicate that Aβ can disrupt excitatory glutamatergic synaptic function …

It is reported that the amyloid-β protein (Aβ)-induced impairments in synaptic plasticity
coincide with memory decline and dementia. Although Aβ-induced inhibition of hippocampal …

Amylin is an important gut-brain axis hormone. Since amylin and amyloid-β peptide (Aβ)
share similar β sheet secondary structure despite not having the same primary sequences …