In the last decade, multiple lines of transgenic APP overexpressing mice have been created
that recapitulate certain aspects of Alzheimer's disease (AD). However, none of the …

One of the central research questions on the etiology of Alzheimer's disease (AD) is the
elucidation of the molecular signatures triggered by the amyloid cascade of pathological …

Alzheimer's disease (AD) pathology is characterized by Aβ peptide‐containing plaques,
neurofibrillary tangles consisting of hyperphosphorylated tau, extensive neuritic …

Alzheimer's disease (AD) is one of the looming health crises of the near future. Increasing
lifespans and better medical treatment for other conditions mean that the prevalence of this …

Autosomal dominant forms of familial Alzheimer's disease (FAD) are associated with
increased production of the amyloid β peptide, Aβ42, which is derived from the amyloid …

Alzheimer's disease (AD) is the most common neurodegenerative affliction of the elderly,
presenting with progressive memory loss and dementia and terminating with death. There …

Alzheimer's disease (AD) is the most common neurodegenerative disease and cause of
dementia. Significant strides toward understanding and developing therapies for AD have …

Alzheimer's disease (AD), the most common cause of dementia among the elderly, may
either represent the far end of a continuum that begins with age-related memory decline or a …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss
and personality changes, eventually leading to dementia. The pathological hallmarks of AD …

Background Knock-in (KI) mouse models of Alzheimer's disease (AD) that endogenously
overproduce Aβ without non-physiological overexpression of amyloid precursor protein …