The 'amyloid cascade hypothesis' links amyloid β peptide (Aβ) with the pathological process
of Alzheimer's disease (AD) and it still awaits universal acceptance. Amyloid precursor …

Alzheimer's disease (AD) is characterized by a substantial degeneration of pyramidal
neurons and the appearance of neuritic plaques and neurofibrillary tangles. Here we …

Biochemical and genetic evidence implicate soluble oligomeric amyloid-β (Aβo) in triggering
Alzheimer's disease (AD) pathophysiology. Moreover, constitutive deletion of the Aβo …

Alzheimer's disease (AD) is a neurodegenerative condition, believed to be irreversible,
characterized by inexorable deterioration of memory and intellect, with neuronal loss …

Mutations in the amyloid precursor protein (APP) gene result in elevated production and
deposition of the 42 amino acid β-amyloid (Aβ1–42) peptide and early-onset Alzheimer's …

Research into the molecular mechanisms of Alzheimer disease (AD) continues to clarify
important issues in aberrant protein processing while seeking to identify therapeutic targets …

Transgenic mouse models of Alzheimer's disease (AD) expressing high levels of amyloid
precursor protein (APP) with familial AD (FAD) mutations have proven to be extremely useful …

Mutations in the genes for amyloid precursor protein (APP) and presenilins (PS1, PS2)
increase production of β-amyloid 42 (Aβ42) and cause familial Alzheimer's disease (FAD) …

Since 1995, more than 100 transgenic (Tg) mouse models of Alzheimer's disease (AD) have
been generated in which mutant amyloid precursor protein (APP) or APP/presenilin 1 (PS1) …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the
presence of extracellular amyloid plaques consisting of Amyloid-β peptide (Aβ) aggregates …