▪ Abstract Alzheimer's disease (AD), the most common dementing disorder of late life, is a
major cause of disability and death in the elderly. Neurobiological, genetic, and molecular …

Alzheimer's disease (AD) can be divided into sporadic AD (SAD) and familial AD (FAD).
Most AD cases are sporadic and may result from multiple etiologic factors, including …

Alzheimer's disease (AD) is a multigenic neurodegenerative disorder characterized by
distinct neuropathological hallmarks including deposits of the β-amyloid (Aβ) peptide. Aβ is …

A variety of Alzheimer's disease (AD) mouse models overexpress mutant forms of human
amyloid precursor protein (APP), producing high levels of amyloid β (Aβ) and forming …

Late-stage neuropathological hallmarks of Alzheimer's disease (AD) are β-amyloid (βA) and
hyperphosphorylated tau peptides, aggregated into plaques and tangles, respectively …

APP overexpressing mice have been widely used in the study of Alzheimer's disease (AD),
focusing mainly at older ages, with higher accumulation of amyloid-β peptide (Aβ). A …

Three mouse models of Alzheimer's disease (AD) were used to assess changes in gene
expression potentially critical to amyloid β-peptide (Aβ)-induced neuronal dysfunction. One …

Alzheimer's disease (AD) is a neurodegenerative pathology in which amyloid-β (Aβ) peptide
accumulates in different brain areas leading to deposition of plaques and a progressive …

We have generated a novel transgenic mouse model on a C57BL/6J genetic background
that coexpresses KM670/671NL mutated amyloid precursor protein and L166P mutated …

Transgenic models of Alzheimer's disease (AD) have made significant contributions to our
understanding of AD pathogenesis, and are useful tools in the development of potential …