Alzheimer's disease (AD) is the most common cause of dementia, affecting 35 million people
today. The search for new treatments is made ever more urgent by prospects for increasing …

Three mouse models of Alzheimer's disease (AD) were used to assess changes in gene
expression potentially critical to amyloid β-peptide (Aβ)-induced neuronal dysfunction. One …

As the scope of the problem of Alzheimer's disease (AD) grows due to an aging population,
research into the devastating condition has taken on added urgency. Rare inherited forms of …

Amyloid-β (Aβ) containing plaques and tau-laden neurofibrillary tangles are the defining
neuropathological features of Alzheimer's disease (AD). To better mimic this …

The amyloid Aβ-peptide (Aβ) is suspected to play a critical role in the cascade leading to AD
as the pathogen that causes neuronal and synaptic dysfunction and, eventually, cell death …

Growing evidence suggests that soluble Aβ species can drive Alzheimer disease (AD)
pathogenesis by inducing a cascade of events including tau hyperphosphorylation …

Neurodegenerative disorders of the aging population affect over 5 million people in the US
and Europe alone. The common feature is the progressive accumulation of misfolded …

Oligomeric forms of amyloid-β peptide (Aβ) are thought to play a pivotal role in the
pathogenesis of Alzheimer's disease (AD), but the mechanism involved is still unclear. Here …

As the average age of the population continues to rise, the number of individuals affected
with age-related cognitive decline and Alzheimer's disease (AD) has increased and is …

A transgenic mouse model for Alzheimer's disease (AD) should mimic the age-dependent
accumulation of β-amyloid plaques, neurofibrillary tangles, neuronal cell death as well as …