Using microarray technology we studied the genome-wide gene expression profiles in the
frontal cortex of APPswe/PS1dE9 mice and age and sex-matched littermates at the age of 2 …

According to the “amyloid hypothesis of Alzheimer's disease,” β-amyloid is the primary
driving force in Alzheimer's disease pathogenesis. Despite the development of many …

Alzheimer's disease is the most widespread form of dementia. Its histopathological
hallmarks include vascular and extracellular β-amyloid (Aβ) deposition and intraneuronal …

Alzheimer's disease (AD) is characterized by memory impairment leading to dementia,
deposition of amyloid plaques and neurofibrillary tangles (NFTs), and neuronal loss. The …

Background Intensive basic and preclinical research into Alzheimer's disease (AD) has
yielded important new findings, but they could not yet been translated into effective …

Within the past decade, our understanding of the pathogenic mechanisms in Alzheimer's
disease (AD) has dramatically advanced because of the development of transgenic mouse …

Background Alzheimer's disease (AD) is the most frequent and costly neurodegenerative
disorder. Although diverse lines of evidence suggest that the amyloid precursor protein …

β-Amyloid (Aβ) pathology is an essential pathogenic component in Alzheimer's disease
(AD). However, the significance of Aβ pathology, including Aβ deposits/oligomers and glial …

The neuropathological correlates of Alzheimer's disease (AD) include amyloid-β (Aβ)
plaques and neurofibrillary tangles. To study the interaction between Aβ and tau and their …

Background Transgenic mice expressing disease-associated proteins have become
standard tools for studying human neurological disorders. Transgenes are often expressed …