Transgenic APP expression during postnatal development causes persistent locomotor hyperactivity in the adult
Background Transgenic mice expressing disease-associated proteins have become
standard tools for studying human neurological disorders. Transgenes are often expressed …
standard tools for studying human neurological disorders. Transgenes are often expressed …
Early diagnosis and treatment of Alzheimer's disease by targeting toxic soluble Aβ oligomers
M Habashi, S Vutla, K Tripathi… - Proceedings of the …, 2022 - National Acad Sciences
Transient soluble oligomers of amyloid-β (Aβ) are toxic and accumulate early prior to
insoluble plaque formation and cognitive impairment in Alzheimer's disease (AD). Synthetic …
insoluble plaque formation and cognitive impairment in Alzheimer's disease (AD). Synthetic …
Transgenic mouse models of Alzheimer's disease: An integrative analysis
R Sanchez-Varo, M Mejias-Ortega… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) constitutes the most prominent form of dementia among elderly
individuals worldwide. Disease modeling using murine transgenic mice was first initiated …
individuals worldwide. Disease modeling using murine transgenic mice was first initiated …
Normal cognition in transgenic BRI2-Aβ mice
Abstract Background Recent research in Alzheimer's disease (AD) field has been focused
on the potential role of the amyloid-β protein that is derived from the transmembrane amyloid …
on the potential role of the amyloid-β protein that is derived from the transmembrane amyloid …
Intracellular amyloid-β accumulation in calcium-binding protein-deficient neurons leads to amyloid-β plaque formation in animal model of Alzheimer's disease
M Moon, HS Hong, DW Nam, SH Baik… - Journal of …, 2012 - content.iospress.com
One of the major hallmarks of Alzheimer's disease (AD) is the extracellular deposition of
amyloid-β (Aβ) as senile plaques in specific brain regions. Clearly, an understanding of the …
amyloid-β (Aβ) as senile plaques in specific brain regions. Clearly, an understanding of the …
Mice as models: transgenic approaches and Alzheimer's disease
D Games, M Buttini, D Kobayashi… - Journal of …, 2006 - content.iospress.com
Progress in understanding and treating Alzheimer's disease (AD) has been tremendously
bolstered by the era of transgenic models of AD. The identification of disease-causing …
bolstered by the era of transgenic models of AD. The identification of disease-causing …
Single and multiple transgenic mice as models for Alzheimer's disease
F van Leuven - Progress in neurobiology, 2000 - Elsevier
Transgenic mice expressing in brain different mutant forms of the Amyloid Precursor Protein,
develop functional, cognitive and pathological defects which resemble or are reminiscent of …
develop functional, cognitive and pathological defects which resemble or are reminiscent of …
Blood-derived amyloid-β protein induces Alzheimer's disease pathologies
XL Bu, Y Xiang, WS Jin, J Wang, LL Shen… - Molecular …, 2018 - nature.com
The amyloid-β protein (Aβ) protein plays a pivotal role in the pathogenesis of Alzheimer's
disease (AD). It is believed that Aβ deposited in the brain originates from the brain tissue …
disease (AD). It is believed that Aβ deposited in the brain originates from the brain tissue …
Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Aβ levels
AM Simón, L Schiapparelli, P Salazar-Colocho… - Neurobiology of …, 2009 - Elsevier
Transgenic mice expressing mutant human amyloid precursor protein (APP) develop an age-
dependent amyloid pathology and memory deficits, but no overt neuronal loss. Here, in mice …
dependent amyloid pathology and memory deficits, but no overt neuronal loss. Here, in mice …
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
Genetic causes of Alzheimer's disease (AD) include mutations in the amyloid precursor
protein (APP), presenilin 1 (PS1), and presenilin 2 (P52) genes1. The mutant APP K670N …
protein (APP), presenilin 1 (PS1), and presenilin 2 (P52) genes1. The mutant APP K670N …