As a result of experimental studies using growing rats1 and pigs2, it has been established
that the developing brain is most vulnerable to restrictions such as undernutrition at the time …

The anatomical and functional architecture of the human brain is mainly determined by
prenatal transcriptional processes. We describe an anatomically comprehensive atlas of the …

Autism spectrum disorder (ASD) involves substantial genetic contributions. These
contributions are profoundly heterogeneous but may converge on common pathways that …

Listen to an interview with Fred Gage on the stem cells podcast The production of
specialized differentiated neurons derived from stem cells has been proposed as a …

AN as-yet unresolved issue in developmental neurobiology is whether the discrete areas
that form the mammalian cortex emerge from a uniform cortical plate or whether they are …

Dementia in Alzheimer's disease progresses alongside neurodegeneration,,–, but the
specific events that cause neuronal dysfunction and death remain poorly understood. During …

Gene expression differs among individuals and populations and is thought to be a major
determinant of phenotypic variation. Although variation and genetic loci responsible for RNA …

Many plants and animals are capable of developing in a variety of ways, forming
characteristics that are well adapted to the environments in which they are likely to live. In …

Background Genetic mutations that cause human disease are conventionally considered to
be inherited from one's parents and present in all somatic (body) cells. We do know …

Neuropsychiatric disorders classically lack defining brain pathologies, but recent work has
demonstrated dysregulation at the molecular level, characterized by transcriptomic and …