Bone development (modeling) occurs by migration, aggregation, and condensation of
immature osteo/chondroprogenitor cells to form the cartilaginous anlage. This process …

Endochondral bone formation requires an elaborate interplay among autocrine, paracrine,
and endocrine signals, positional cues, and cell‐cell contacts to mediate the complex three …

THE ORGANIZATION OF CELLS in tissues and organs is con-trolled by molecular programs
that afford cells the ability to recognize their neighbors and the extracellular matrix. Cell–cell …

Osteoclasts are multinucleated cells of hemopoietic origin that are responsible for bone
resorption during physiological bone remodeling and in a variety of bone diseases …

Cell–cell and cell–matrix interactions mediated by cell adhesion molecules are important
mechanisms controlling cell fate and function. Here, we review recent advances in the …

Direct cell-to-cell interactions via cell adhesion molecules, in particular cadherins, are critical
for morphogenesis, tissue architecture, and cell sorting and differentiation. Partially …

There is increasing evidence that osteocytes regulate multiple aspects of bone remodeling
through bi‐directional communication with osteoblasts. This is potentially mediated through …

E-cadherin, a protein responsible for intercellular adhesion between epithelial cells, is also
expressed in the monocyte/macrophage lineage. In this study we have explored the …

Coordinated actions of osteoblasts and osteoclasts are required to maintain the integrity of
the skeleton. This is achieved, in part, by a highly regulated array of molecules that are …

Cells in osteoclast and osteoblast lineages communicate with each other through cell–cell
contact, diffusible paracrine factors and cell–bone matrix interaction. Osteoclast–osteoblast …