Heart failure (HF) remains the most common cause of death and disability, and a major
economic burden, in industrialized nations. Physiological, pharmacological, and clinical …

The renin-angiotensin system (RAS) plays a major role in the pathophysiology of
cardiovascular disorders. Angiotensin II (Ang-II), the final product of this pathway, is known …

Abstract Angiotensin-converting enzyme 2 (ACE2) is a monocarboxypeptidase that
metabolizes several peptides, including the degradation of angiotensin (Ang) II, a peptide …

Background ACE2 is a novel homologue of angiotensin converting enzyme (ACE). ACE2 is
highly expressed in human heart and animal data suggest that ACE2 is an essential …

A novel angiotensin-converting enzyme (ACE) homolog, named ACE2, is a
monocarboxypeptidase which metabolizes several peptides. ACE2 degrades Angiotensin …

The RAS (renin–angiotensin system) is activated after MI (myocardial infarction), and RAS
blockade with ACEis [ACE (angiotensin-converting enzyme) inhibitors] or ARBs (angiotensin …

Objectives: We sought to determine whether circulating soluble angiotensin-converting
enzyme 2 (sACE2) is increased in the plasma of patients with heart failure (HF) …

The renin–angiotensin system (RAS) has pivotal roles in the regulation of normal physiology
and the pathogenesis of cardiovascular disease. Angiotensin-converting enzyme (ACE) 2 …

Background: The renin-angiotensin system (RAS) is activated in heart failure (HF) and
inhibition of RAS is a mainstay therapy for HF. Angiotensin-converting enzyme 2 (ACE2) and …

Cardiovascular disease is predicted to be the commonest cause of death worldwide by the
year 2020. Diabetes, smoking and hypertension are the main risk factors. The renin …