Racial differences in the relationship between rate of nicotine metabolism and nicotine intake from cigarette smoking
KC Ross, NR Gubner, RF Tyndale, LW Hawk Jr… - Pharmacology …, 2016 - Elsevier
Rate of nicotine metabolism has been identified as an important factor influencing nicotine
intake and can be estimated using the nicotine metabolite ratio (NMR), a validated …
intake and can be estimated using the nicotine metabolite ratio (NMR), a validated …
The nicotine metabolite ratio is associated with early smoking abstinence even after controlling for factors that influence the nicotine metabolite ratio
MJ Chenoweth, RA Schnoll, M Novalen… - Nicotine & Tobacco …, 2016 - academic.oup.com
Introduction: The decrease in smoking rates in North America has plateaued, underscoring
the need for new approaches to treat nicotine dependence. Inter-individual differences in …
the need for new approaches to treat nicotine dependence. Inter-individual differences in …
Disposition kinetics and metabolism of nicotine and cotinine in African American smokers: impact of: CYP2A6: genetic variation and enzymatic activity
NL Benowitz, GS Helen, DA Dempsey… - Pharmacogenetics …, 2016 - journals.lww.com
Objective The rate of nicotine metabolism, determined primarily by CYP2A6 activity,
influences tobacco dependence and smoking-induced disease risk. The prevalence of …
influences tobacco dependence and smoking-induced disease risk. The prevalence of …
Nicotine metabolite ratios in serum and urine among US adults: variations across smoking status, gender and race/ethnicity
RB Jain - Biomarkers, 2020 - Taylor & Francis
Purpose: The objective of this study was to evaluate factors affecting variabilities in the
observed levels of nicotine metabolite ratios in serum (NMRS, N= 10,234) and urine (NMRU …
observed levels of nicotine metabolite ratios in serum (NMRS, N= 10,234) and urine (NMRU …
Race, gender, and nicotine metabolism in adolescent smokers
Introduction: Differences in the rate of nicotine metabolism between genders and different
races have been hypothesized to contribute to disparities in smoking rate, susceptibility to …
races have been hypothesized to contribute to disparities in smoking rate, susceptibility to …
Adolescent nicotine metabolism
ET Moolchan, FH Franken, M Jaszyna-Gasior - Ethnicity & Disease, 2006 - JSTOR
Variations in nicotine metabolism are thought to contribute to differences in cigarette
consumption between African Americans and Caucasian adult smokers. To investigate the …
consumption between African Americans and Caucasian adult smokers. To investigate the …
The relationship between the nicotine metabolite ratio and three self-report measures of nicotine dependence across sex and race
Rationale Variability in the rate of nicotine metabolism, measured by the nicotine metabolite
ratio (NMR), is associated with smoking behavior. However, data linking the NMR with …
ratio (NMR), is associated with smoking behavior. However, data linking the NMR with …
Nicotine metabolite ratio: Comparison of the three urinary versions to the plasma version and nicotine clearance in three clinical studies
HK Giratallah, MJ Chenoweth, N Addo… - Drug and alcohol …, 2021 - Elsevier
Abstract Background Variation in CYP2A6 activity influences tobacco smoking behaviors
and smoking-related health outcomes. Plasma Nicotine Metabolite Ratio (NMR) is a robust …
and smoking-related health outcomes. Plasma Nicotine Metabolite Ratio (NMR) is a robust …
[HTML][HTML] Individual differences in nicotine kinetics and metabolism in humans
NL Benowitz, P Jacob - NIDA Res Monogr, 1997 - books.google.com
Cigarette smoking remains the major preventable cause of premature disability and death in
developed countries (Peto et al. 1992). Cigarette smoking is maintained by addiction to …
developed countries (Peto et al. 1992). Cigarette smoking is maintained by addiction to …
Reproducibility of the nicotine metabolite ratio in cigarette smokers
G St. Helen, M Novalen, DF Heitjan, D Dempsey… - … , biomarkers & prevention, 2012 - AACR
Background: The nicotine metabolite ratio (NMR or 3-hydroxycotinine/cotinine) has been
used to phenotype CYP2A6-mediated nicotine metabolism. Our objectives were to analyze …
used to phenotype CYP2A6-mediated nicotine metabolism. Our objectives were to analyze …
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