Racial differences in the relationship between rate of nicotine metabolism and nicotine intake from cigarette smoking

KC Ross, NR Gubner, RF Tyndale, LW Hawk Jr… - Pharmacology …, 2016 - Elsevier
Rate of nicotine metabolism has been identified as an important factor influencing nicotine
intake and can be estimated using the nicotine metabolite ratio (NMR), a validated …

The nicotine metabolite ratio is associated with early smoking abstinence even after controlling for factors that influence the nicotine metabolite ratio

MJ Chenoweth, RA Schnoll, M Novalen… - Nicotine & Tobacco …, 2016 - academic.oup.com
Introduction: The decrease in smoking rates in North America has plateaued, underscoring
the need for new approaches to treat nicotine dependence. Inter-individual differences in …

Disposition kinetics and metabolism of nicotine and cotinine in African American smokers: impact of: CYP2A6: genetic variation and enzymatic activity

NL Benowitz, GS Helen, DA Dempsey… - Pharmacogenetics …, 2016 - journals.lww.com
Objective The rate of nicotine metabolism, determined primarily by CYP2A6 activity,
influences tobacco dependence and smoking-induced disease risk. The prevalence of …

Nicotine metabolite ratios in serum and urine among US adults: variations across smoking status, gender and race/ethnicity

RB Jain - Biomarkers, 2020 - Taylor & Francis
Purpose: The objective of this study was to evaluate factors affecting variabilities in the
observed levels of nicotine metabolite ratios in serum (NMRS, N= 10,234) and urine (NMRU …

Race, gender, and nicotine metabolism in adolescent smokers

ML Rubinstein, S Shiffman, MA Rait… - Nicotine & tobacco …, 2013 - academic.oup.com
Introduction: Differences in the rate of nicotine metabolism between genders and different
races have been hypothesized to contribute to disparities in smoking rate, susceptibility to …

Adolescent nicotine metabolism

ET Moolchan, FH Franken, M Jaszyna-Gasior - Ethnicity & Disease, 2006 - JSTOR
Variations in nicotine metabolism are thought to contribute to differences in cigarette
consumption between African Americans and Caucasian adult smokers. To investigate the …

The relationship between the nicotine metabolite ratio and three self-report measures of nicotine dependence across sex and race

RA Schnoll, TP George, L Hawk, P Cinciripini… - …, 2014 - Springer
Rationale Variability in the rate of nicotine metabolism, measured by the nicotine metabolite
ratio (NMR), is associated with smoking behavior. However, data linking the NMR with …

Nicotine metabolite ratio: Comparison of the three urinary versions to the plasma version and nicotine clearance in three clinical studies

HK Giratallah, MJ Chenoweth, N Addo… - Drug and alcohol …, 2021 - Elsevier
Abstract Background Variation in CYP2A6 activity influences tobacco smoking behaviors
and smoking-related health outcomes. Plasma Nicotine Metabolite Ratio (NMR) is a robust …

[HTML][HTML] Individual differences in nicotine kinetics and metabolism in humans

NL Benowitz, P Jacob - NIDA Res Monogr, 1997 - books.google.com
Cigarette smoking remains the major preventable cause of premature disability and death in
developed countries (Peto et al. 1992). Cigarette smoking is maintained by addiction to …

Reproducibility of the nicotine metabolite ratio in cigarette smokers

G St. Helen, M Novalen, DF Heitjan, D Dempsey… - … , biomarkers & prevention, 2012 - AACR
Background: The nicotine metabolite ratio (NMR or 3-hydroxycotinine/cotinine) has been
used to phenotype CYP2A6-mediated nicotine metabolism. Our objectives were to analyze …