The present study was undertaken to determine the effects of cyclooxygenase (COX)
inhibitors on the development of neuropathic pain in rats following chronic constriction injury …

There are several lines of evidence to suggest that cyclooxygenase-2 (COX-2) plays an
important role in the generation and maintenance of neuropathic pain states following …

After nerve injury, cyclooxygenase-2 (COX-2) is upregulated in spinal cord and peripheral
nerve, the latter being dependent on tumor necrosis factor-alpha (TNF). Here we asked …

Cyclooxygenase-2 (COX-2) after induction peripherally, and within the CNS, plays an
important role in producing inflammatory pain. However, its role in neuropathic pain models …

Mechanical hyperalgesia induced in rat paws by carrageenan (250μg) was modified by pre-
treatment with three selective inhibitors of cyclo-oxygenase-2 (COX-2); celecoxib, rofecoxib …

The effectiveness of non-steroidal anti-inflammatory drugs (NSAIDs) in treating neuropathic
pain caused by nerve injury has been controversial. In the present study, 4 weeks following …

Administration of formalin in rat paws results in stimulation of nociceptive pathways, which
leads to an increase in the excitability of neurons present in dorsal horn. This increased …

Prostaglandins (PGs) are known to be involved in inflammatory and nociceptive processing.
Since the discovery of at least two isozymes of cyclooxygenase (COX), inhibition of COX-2 …

Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits
cyclooxygenase-2 (COX-2). Like most NSAIDs, celecoxib exhibits analgesic effects in …

Non-steroidal antiinflammatory drugs (NSAIDs) inhibit the cyclooxygenase (COX) enzyme
and so they are effective analgesic, antiinflammatory and antipyretic drugs. The discovery of …