Edgeworthia gardneri (Wall.) Meisn. Water Extract Ameliorates Palmitate Induced Insulin Resistance by Regulating IRS1/GSK3β/FoxO1 Signaling Pathway in Human …

Y Zhang, LS Yan, Y Ding, BCY Cheng, G Luo… - Frontiers in …, 2020 - frontiersin.org
The flower of Edgeworthia gardneri (Wall.) Meisn is commonly used in beverage products in
Tibet and has potential health benefits for diabetes. However, the mechanisms underlying …

Artichoke (Cynara scolymus L.) water extract alleviates palmitate-induced insulin resistance in HepG2 hepatocytes via the activation of IRS1/PI3K/AKT/FoxO1 and …

A Deng, Y Wang, K Huang, P Xie, P Mo, F Liu… - … Medicine and Therapies, 2023 - Springer
Abstract Background Artichoke (Cynara scolymus L.) is a typical element of a traditional
Mediterranean diet and has potential health advantages for insulin resistance (IR) and type …

Aspalathin-enriched green rooibos extract reduces hepatic insulin resistance by modulating PI3K/AKT and AMPK pathways

SE Mazibuko-Mbeje, PV Dludla, C Roux… - International journal of …, 2019 - mdpi.com
We previously demonstrated that an aspalathin-enriched green rooibos extract (GRE)
reversed palmitate-induced insulin resistance in C2C12 skeletal muscle and 3T3-L1 fat cells …

Four sesquiterpene glycosides from loquat (Eriobotrya japonica) leaf ameliorates palmitic acid-induced insulin resistance and lipid accumulation in HepG2 Cells via …

J Li, X Ding, T Jian, H Lü, L Zhao, J Li, Y Liu, B Ren… - PeerJ, 2020 - peerj.com
Insulin resistance (IR), caused by impaired insulin signal and decreased insulin sensitivity,
is generally responsible for the pathophysiology of type 2 diabetes mellitus (T2DM) …

A diarylheptanoid compound from Alpinia officinarum Hance ameliorates high glucose-induced insulin resistance by regulating PI3K/AKT-Nrf2-GSK3β signaling …

X Zhang, A Liu, Y Zhang, M Zhou, X Li, M Fu… - Journal of …, 2022 - Elsevier
Abstract Ethnopharmacological relevance Alpinia officinarum Hance, a perennial natural
medicine-food herb, has been traditionally used to treat colds, stomachache, and diabetes …

Paeoniflorin suppresses lipid accumulation and alleviates insulin resistance by regulating the Rho kinase/IRS-1 pathway in palmitate-induced HepG2Cells

Z Ma, H Liu, W Wang, S Guan, J Yi, L Chu - Biomedicine & …, 2017 - Elsevier
In this study, we evaluated the effects of paeoniflorin (PF) on palmitate (PA)-induced insulin
resistance and explored the potential molecular mechanisms in HepG2 cells. HepG2 cells …

Protective effects of marein on high glucose-induced glucose metabolic disorder in HepG2 cells

B Jiang, L Le, W Zhai, W Wan, K Hu, P Yong, C He… - Phytomedicine, 2016 - Elsevier
Background Our previous study has shown that Coreopsis tinctoria increases insulin
sensitivity and regulates hepatic metabolism in high-fat diet (HFD)-induced insulin …

Tectorigenin attenuates palmitate-induced endothelial insulin resistance via targeting ROS-associated inflammation and IRS-1 pathway

Q Wang, XL Cheng, DY Zhang, XJ Gao, L Zhou… - PLoS …, 2013 - journals.plos.org
Tectorigenin is a plant isoflavonoid originally isolated from the dried flower of Pueraria
thomsonii Benth. Although its anti-inflammatory and anti-hyperglycosemia effects have been …

Epigallocatechin gallate improves insulin resistance in HepG2 cells through alleviating inflammation and lipotoxicity

Q Zhang, H Yuan, C Zhang, Y Guan, Y Wu… - Diabetes Research and …, 2018 - Elsevier
Aims High levels of circulating free fatty acids (FFAs), inflammation and oxidative stress are
important causes for insulin resistance (IR) and type 2 diabetes mellitus. The aim of this …

Sea buckthorn fruit oil extract alleviates insulin resistance through the PI3K/Akt signaling pathway in type 2 diabetes mellitus cells and rats

S Gao, Q Guo, C Qin, R Shang… - Journal of agricultural and …, 2017 - ACS Publications
Sea buckthorn fruit oil is rich in palmitoleic acid (POA), which has been reported to play roles
in many metabolic processes. In this study, a sea buckthorn fruit oil (SBFO) extract was …