Cell death and inflammation are intimately linked during Yersinia infection. Pathogenic
Yersinia inhibits the MAP kinase TGFβ-activated kinase 1 (TAK1) via the effector YopJ …

Gasdermin D (GSDMD) is a pore-forming protein that promotes pyroptosis and release of
proinflammatory cytokines. Recent studies revealed that apoptotic caspase-8 directly …

Cell death plays a critical role in inflammatory responses. During pyroptosis, inflammatory
caspases cleave Gasdermin D (GSDMD) to release an N-terminal fragment that generates …

Limited proteolysis of gasdermin D (GSDMD) generates an N-terminal pore-forming
fragment that controls pyroptosis in macrophages. GSDMD is processed via inflammasome …

Injection of effector proteins to block host innate immune signaling is a common strategy
used by many pathogenic organisms to establish an infection. For example, pathogenic …

Pyroptosis was long regarded as caspase-1-mediated monocyte death in response to
certain bacterial insults. Caspase-1 is activated upon various infectious and immunological …

Journal Club Journal Club Journal Club Page 1 www.nature.com/nri 0123456789();: ReseaRch
highlights 620 | oCToBeR 2021 | voLuMe 21 Pathogeninduced inflammation manifests as an …

Pyroptosis is an inflammatory form of cell death that not only protects multicellular organisms
from invading pathogenic bacteria and microbial infections, but can also lead to sepsis and …

INTRODUCTION An inflammatory innate immune response is a first line of host defense
against invading pathogens. Inflammation recruits immune cells to the infection site and …

Summary Either caspase-1 or caspase-11 can cleave gasdermin D to cause pyroptosis,
eliminating intracellular replication niches. We previously showed that macrophages detect …