Memory CD8 T cells, generated by natural pathogen exposure or intentional vaccination,
protect the host against specific viral infections. It has long been proposed that the number of …

A hallmark of adaptive immunity is the generation of memory T cells that confer long-lived,
antigen-specific protection against repeat challenges by pathogens,,,,. Understanding the …

It is thought that immunity depends on naïve CD4 T cells that proliferate in response to
microbial antigens,,,, differentiate into memory cells that produce anti-microbial …

The differentiation of human memory CD8 T cells is not well understood. Here we address
this issue using the live yellow fever virus (YFV) vaccine, which induces long-term immunity …

Immunization in the absence of CD4+ T cell help results in defective CD8+ T cell memory,
deficient recall responses and diminished protective immunity. Here we investigated at what …

Memory CD8 T cells that circulate in the blood and are present in lymphoid organs are an
essential component of long-lived T cell immunity. These memory CD8 T cells remain …

Abstract Although interleukin-2 (IL-2) was initially characterized as the primary T-cell growth
factor following in vitro activation, less is known about its role in shaping T-cell responses to …

ALTHOUGH some viruses, particularly the herpes viruses, may never be eliminated from the
body1, others like influenza A, regularly reinfect humans and boost waning crossreactive …

MEMORY is a hallmark of the immune system and ever since its recognition there has been
considerable interest in understanding how immunity is maintained1–5. The current model …

Of the many dendritic cell (DC) subsets, DCs expressing the monomorphic coreceptor CD8
α-chain (CD8α) are localized permanently in lymphoid organs, whereas' tissue-derived DCs' …