Several studies have indicated that CD8+ T cells require CD4+ T cell help for memory
formation. Evidence suggests that such help can be antigen independent, challenging …

Memory CD8 T cells persist by Ag-independent homeostatic proliferation. To examine the
dynamics of this cell turnover, we transferred lymphocytic choriomeningitis virus specific …

The CD4+ T-cell pool in HIV-infected patients is in a constant state of flux as CD4+ T cells
are infected and destroyed by HIV and new cells take their place. To study T-cell survival, we …

The ability to develop and sustain populations of memory T cells after infection or
immunization is a hallmark of the adaptive immune response and a basis for protective …

Following infection, naïve CD8+ T cells bearing pathogen-specific T cell receptors (TCRs)
differentiate into a mixed population of short-lived effector and long-lived memory T cells to …

The magnitude of antigen-specific CD8+ T cell responses is not fixed but correlates with the
severity of infection. Although by definition T cell response size is the product of both the …

After an infection, pathogen-specific tissue-resident memory T cells (TRM cells) persist in
nonlymphoid tissues to provide rapid control upon reinfection, and vaccination strategies …

Many intracellular pathogens infect a broad range of host tissues, but the importance of T
cells for immunity in these sites is unclear because most of our understanding of …

In response to infection, antigen‐specific CD8+ T cells undergo massive expansion in
numbers, acquire effector mechanisms, and disseminate throughout the body. The …

After viral infection, naive CD8+ T cells become activated and either differentiate into effector
cells, which eliminate virus-infected cells, or convert to memory-type T cells, awaiting re …