Spermatogonial stem cells (SSCs) must maintain the integrity of their genome to prevent
reproduction failure and limit the hereditary risk associated with transmission to the progeny …

DNA damage response in adult spermatogenic cells should limit the propagation of
mutations to the offspring, without being detrimental to fertility. In differentiating …

Spermatocytes normally sustain many meiotically induced double‐strand DNA breaks
(DSBs) early in meiotic prophase; in autosomal chromatin, these are repaired by initiation of …

Purpose Testicular spermatogenesis is extremely sensitive to radiation-induced damage,
and even low scattered doses to testis from radiation therapy may pose reproductive risks …

Lifelong mammalian male fertility is maintained through an intricate balance between
spermatogonial proliferation and differentiation. DNA damage in spermatogonia, for …

Spermatogenesis is highly orchestrated and involves the differentiation of diploid
spermatogonia into haploid sperm. The process is driven by spermatogonial stem cells …

Germ cells are thought to exhibit a unique DNA damage response that differs from that of
somatic stem cells, and previous studies suggested that Trp53 is not involved in the survival …

This review surveys the causes and consequences of DNA damage in the male germ line
from spermatogonial stem cells to fully differentiated spermatozoa. Within the stem cell …

Background Germ cells have a unique and critical role as the conduit for hereditary
information and therefore employ multiple strategies to protect genomic integrity and avoid …

Spermatogonial stem cells (SSCs) are the ultimate germline stem cells with the potential of
self-renewal and differentiation, and a dynamic balance of SSCs play an essential role in …