HOM-C/Hox genes are important regulatory genes that control structural polarity, cell fate,
and pattern formation in vertebrate development. Retinoic acid (RA) activates and regulates …

Cell-specific restrictions in expression of HOM-C/Hox homeobox genes are critical for proper
control of pattern formation and cell identity during vertebrate development. During fetal lung …

Genes of the HOMC complex (Hox genes) are important controllers of structural polarity and
cell fate in vertebrate development. Retinoic Acid (RA) plays a critical role in regulating …

Hoxa-5 is a homeobox gene that is highly expressed in the developing mouse lung.
However, little is known about the molecular mechanisms controlling expression. We …

We have previously described a 5cis‐acting retinoic acid response element that is required
for a subset of Hoxa4 expression, including the midgestation mouse lung. As both retinoids …

It has finally happened. Once the domain of molecular embryologists, Hox genes are now
the subject of investigation in the study of the biology of specific cell and tissue types such as …

BACKGROUND: Hox transcription factors modulate signaling pathways controlling organ
morphogenesis and maintain cell fate and differentiation in adults. Retinoid signaling, key in …

Hox genes code for transcription factors that define pattern formation and organ structure in
the developing embryo. We have previously shown that the expression pattern and …

Hox genes are sequence-specific DNA transcription factors, which are important in
embryonic development and are expressed in a number of fetal tissues, including the lung …

Exogenous retinoids alter pattern formation and differentiation in many developing systems,
such as limb, vertebrae, and central nervous system. Many of these effects are mediated by …