Publisher Summary This chapter focuses on the role of gap junctional intercellular
communication (GJIC) in cellular growth control and neoplasia and considers the large body …

Most, if not all, cancer cells have some dysfunction in gap-junction-mediated intercellular
communication, either because of defects in cell adhesion or inability to have functional gap …

Gap junctional intercellular communication plays a key role in the maintenance of
homeostasis in multicellular organisms. Reflecting deranged homeostasis in cancer cells …

The mechanistic relationship of the inhibition of gap junctional intercellular communication
(GJIC) to other toxicological phenomena was explored using a recently developed method …

Hanahan and Weinberg (2000, Cell 100: 57‐70) listed “hallmarks” of cancer that must be
considered in order to understand the underlying determinants of carcinogenesis:(a) self …

In multicellular organisms, the role of gap junction intercellular communication (GJIC) in the
regulation of cell proliferation, cell differentiation, and apoptosis is becoming increasingly …

During the evolution of single-celled organisms to multicellular metazoans, a family of highly
conserved genes coding for proteins (connexins), which as hexameric units (connexons) …

Fifty years ago, tumour cells were found to lack electrical coupling, leading to the hypothesis
that loss of direct intercellular communication is commonly associated with cancer onset and …

Gap junctional intercellular communication (GJIC) is considered to play a key role in the
maintenance of tissue independence and homeostasis in multicellular organisms by …

Cancer was one of the first pathologies to be associated with gap-junction defect. Despite
the evidence accumulated over the last 40-year period, the molecular involvement of gap …