Many studies have correlated reductions in gap junctional intercellular communication (a)
with altered cellular growth, tumor promotion, and neoplastic transformation. To test directly …

During multistage carcinogenesis, multiple genetic changes progressively accumulate in a
cell until it acquires a complete set of altered genes necessary for malignant phenotype …

Objectives. Gap junctional intercellular communication (GJIC) is believed to play an
important role in the maintenance of cell homeostasis, and its disruption may be associated …

Numerous studies have demonstrated a correlation between dysregulation/loss of connexin
expression or gap junction intercellular communication (GJIC) function and decreased …

Connexins (Cx), which constitute gap junction intercellular channels in vertebrates, have
been shown to suppress transformed cell growth and tumorigenesis, but the mechanism (s) …

Gap‐junction‐mediated intercellular communication (GJIC) is required for completion of
embryonic development, tissue homeostasis, and regulation of cell proliferation and death …

Abstract Trosko, JE and Chang, CC Role of Stem Cells and Gap Junctional Intercellular
Communication in Human Carcinogenesis. Epidemiological data, experimental animal …

Gap junctions (GJs) provide cell-to-cell communication of essential metabolites and ions.
GJs allow tissues to average responses, clear waste products, and minimize the effects of …

Formation of metastases negatively impacts the survival prognosis of cancer patients.
Globally, if the various steps involved in their formation are relatively well identified, the …

There is a large body of evidence suggesting the connexin gap junction proteins appear to
act as tumor suppressors, and their tumor inhibitory effect is usually attributed to their main …