Mitochondrial damage and dysfunction occur during ischemia and modulate cardiac
function and cell survival significantly during reperfusion. We hypothesized that …

Previously, we demonstrated that ischemia induces mitochondrial damage and dysfunction
that persist throughout reperfusion and impact negatively on postischemic functional …

Ischemic heart disease remains the leading cause of death worldwide. Mitochondria are the
power plant of the cardiomyocyte, generating more than 95% of the cardiac ATP. Complex …

We have previously shown that transplantation of autologously derived, respiration-
competent mitochondria by direct injection into the heart following transient ischemia and …

Mitochondrial dysfunction is the determinant insult of ischemia-reperfusion injury.
Autologous mitochondrial transplantation involves supplying one's healthy mitochondria to …

Background We have previously demonstrated the efficacy of mitochondrial transplantation
(MT) for the treatment of ischemia-reperfusion injury (IRI). We now investigate the efficacy of …

Mitochondria play a key role in the homeostasis of the vast majority of the body's cells. In the
myocardium where mitochondria constitute 30% of the total myocardial cell volume …

Tissue ischemia adversely affects the function of mitochondria, which results in impairment
of oxidative phosphorylation and compromised recovery of the affected organ. The impact of …

A recent study showed that the injection of mitochondria isolated from a nonischemic region
mitigated myocardial injury. We tested the protective effects of infusing isolated mitochondria …

Objective To demonstrate the clinical efficacy of autologous mitochondrial transplantation in
preparation for translation to human application using an in vivo swine model. Methods A left …