Abstract Since Isaac's and Lindenmann's seminal experiments over 50 years ago
demonstrating a soluble factor generated from heat killed virus-stimulated chicken embryos …

Highlights•IFN-I signaling has recently been shown to contribute to viral immune
pathologies.•Elevated IFN-I signatures are found in persistent virus infections in multiple …

Following virus infections, type I interferons are synthesized to induce the expression of
antiviral molecules and interfere with virus replication. The importance of early antiviral type I …

Type I interferons (IFN-I) have long been heralded as key contributors to effective antiviral
responses. More widely understood in the context of acute viral infection, the role of this …

Type I interferons (IFNs) are a family of cytokines specialized to coordinate immunity to
viruses and other intracellular infections. In the past several years, many of the receptors …

Type I interferon (IFN), as its name implies,'interferes' with virus replication by activating
numerous genes. Further, virus-induced type I IFN regulates the magnitude and functions of …

Type I interferons (IFNs)(IFN-α, IFN-β) and type III IFNs (IFN-λ) share many properties,
including induction by viral infection, activation of shared signaling pathways, and …

Highlights•Type III interferons are antiviral factors that are expressed in response to
numerous viral infections.•Type III interferons are most crucial for controlling viral infections …

Over half a century has passed since interferons (IFNs) were discovered and shown to
inhibit virus infection in cultured cells. Since then, researchers have steadily brought to light …

Type I interferons (IFNs) are pro-inflammatory cytokines that are rapidly induced in different
cell types during viral infections. The consequences of type I IFN signalling include direct …